Establishment of the method of selecting in vitro matured oocyte with high developmental competence by morphological evaluation of metaphase spindle.
| Project/Area Number |
21780250
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied animal science
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| Research Institution | Tohoku University |
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Principal Investigator |
HOSHINO Yumi 東北大学, 大学院・農学研究科, 助教 (10451551)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | マウス / 卵子 / 体外成熟培養 / 卵子の質評価 / 受精能・発生能 / 紡錘体 / 卵子の質 / MTOC / 微小管の安定性 / 受精能・発生能評価 / Akt |
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| Research Abstract |
It is important to identify reliable indicators of oocyte quality for efficient embryo production and infertility treatment. Determination of oocyte quality by morphological assessment is a relatively popular method because it is noninvasive and convenient. In this study, the feature of the high quality oocyte was clarified based on the meiotic spindle of a mature oocyte. Furthermore, the factor in connection with this was identified and the index which leads to evaluation of the quality of an oocyte was established based on the result in a molecular level.
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Report
(4 results)
Research Products
(34 results)
