The roles of methylation pathway in epigenetics of bovine preimplantation embryos
| Project/Area Number |
21780251
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied animal science
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| Research Institution | Kyoto University |
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Principal Investigator |
IKEDA Shuntaro Kyoto University, 大学院・農学研究科, 助教 (50447893)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ウシ / 卵母細胞 / 着床前胚 / 栄養と繁殖 / メチル基経路 / エピジェネティクス / 胚盤胞 / 葉酸・メチオニンサイクル / メチオニン / 初期胚 |
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| Research Abstract |
We demonstrated that (1) bovine oocytes and preimplantation embryos express methylation pathway enzymes ; (2) among the metabolites in methylation pathway, homocysteine affects the level of DNA methylation, and methionine, thorough its conversion to S-adenosylmethionine, is involved in morula-to-blastocyst transition during bovine preimplantation development. The existence and importance of methylation pathway in bovine preimplantation development were suggested.
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Report
(3 results)
Research Products
(10 results)
