Signaling pathway in amino acids mediated suppression of muscle proteolysis
| Project/Area Number |
21780256
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied animal science
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| Research Institution | National Agricultural Research Organization |
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Principal Investigator |
NAKASHIMA Kazuki 独立行政法人農業・食品産業技術総合研究機構, 畜産草地研究所・分子栄養研究チーム, 主任研究員 (70370583)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アミノ酸 / タンパク質分解 / タンパク質分解関連遺伝子発現 / 筋肉細胞培養 / アトロジン-1 / ロイシン / アミノ酸トランスポーター / siRNA干渉 / IGF-I |
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| Research Abstract |
The present study addressed the role of amino acids as a regulator of proteolysis in myotubes. Leucine and glutamine suppressed proteolysis, while also decreasing expression of atrogin-1 mRNA through the L- system amino acid transporter (LAT1). Amino acids did not activate AKT-FOXO signaling pathway, but inhibiting proteolysis. Thus, an important component of muscle proteolysis inhibition by leucine or amino acids, through LAT1 but not AKT-FOXO signaling pathway, is its ability to suppress muscle protein degradation.
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Report
(3 results)
Research Products
(2 results)
