| Project/Area Number |
21780259
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied animal science
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| Research Institution | National Institute of Agrobiological Sciences |
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Principal Investigator |
SAKUMOTO Ryosuke National Institute of Agrobiological Sciences, 生殖機構研究ユニット, 主任研究員 (20343999)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ウシ / 生殖 / 妊娠 / 卵巣 / 黄体 / 子宮 / 受胎率 / サイトカイン |
|---|
| Research Abstract |
To determine whether pregnant-specific substances are produced in the bovine corpus luteum (CL), this study evaluated the differences of gene and protein expressions between in the pregnant and in nonpregnant CL. Physiological roles of cytokines and steroids in the bovine CL and endometrial functions are also investigated. As a result, gene expressions of several substances such as prostaglandin receptors or tumor necrosis factor (TNF) are more abundant in the pregnant CL. Moreover, cellular localization of TNF and progesterone receptors in the bovine CL and endometrium are clarified in the present study. Thus, the present study provides a new concept in regulating CL and endometrial function in cows.
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