Investigation for the mechanisms of the emergence of brown adipocytes in white adipose tissue

• Project/Area Number: 21780261
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Hokkaido University
• Principal Investigator: OKAMATSU Yuko Hokkaido University, 大学院・獣医学研究科, 助教 (90527178)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脂肪細胞 / 褐色脂肪 / 肥満 / 脱共役蛋白質 / 脱共役タンパク質

Research Abstract

Brown adipose tissue (BAT) is a tissue specified for metabolic heat production and expected to be a target for the treatment of obesity. To maximize the anti-obesity effect of BAT thermogenesis, activation of the thermogenic function or induction of tissue hyperplasia would be effective. Generally, the number of adipocyte is controlled by the proliferation of pre-adipocytes and their differentiation. In this study, we revealed that brown adipocytes proliferate not only before, but also after their differentiation.

Research Products

• [Journal Article] Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype (2010)
  • Author(s): Sawada T
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] 褐色脂肪細胞によるエネルギー代謝制御におけるPGC-1の役割 (2009)
  • Author(s): 岡松優子、木村和弘
  • Journal Title: 内分泌・糖尿病科 29 Pages: 109-116
• [Journal Article] High incidence of metabolically active brown adipose tissue in healthy adult humans : effects of cold exposure and adiposity. (2009)
  • Author(s): Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M.
  • Journal Title: Diabetes. 58(7) Pages: 1526-1531
  • Peer Reviewed
• [Presentation] Thermogenic UCP1 controls appetite through modulation of leptin sensitivity (2009)
  • Author(s): Yuko Okamatsu-Ogura、Akira Terao、Kazuhiro Kimura、Masayuki Saito
  • Organizer: The 3^<rd> International Symposium on Physiology and Pharmacology of Temperature Regulation
  • Place of Presentation: くにびきメッセ(松江)
  • Year and Date: 2009-07-24
• [Presentation] Thermogenic UCP1 controls appetite through modulation of leptin sensitivity (2009)
  • Author(s): Yuko Okamatsu-Ogura
  • Organizer: The 3^<rd> International Symposium on Physiology and Pharmacology of Temperature Regulation
  • Place of Presentation: 松江、くにびきメッセ
  • Year and Date: 2009-07-24
• [Presentation] Protective roles of brown adipose tissue against age-related development of obesity (2009)
  • Author(s): Yuko Okamatsu-Ogura、Masayuki Saito
  • Organizer: 14^<th> International Congress of Endocrinology Official Satellite Symposium "Obesity and Metabolic Syndrome"
  • Place of Presentation: 芝蘭会館(京都)
  • Year and Date: 2009-03-31
• [Presentation] Protective roles of brown adipose tissue against age-related development of obesity (2009)
  • Author(s): Yuko Okamatsu-Ogura
  • Organizer: 14^<th> International Congress of Endocrinology Official Satellite Symposium "Obesity and Metabolic Syndrome"
  • Place of Presentation: 京都、芝蘭会館
  • Year and Date: 2009-03-31
• [Presentation] Thermogenic UCP1 enhances anorexigenic effect of leptin in mice (2009)
  • Author(s): Yuko Okamatsu-Ogura、Akira Terao、Kazuhiro Kimura、Masayuki Saito
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都国際会館(京都)
  • Year and Date: 2009-03-30
• [Presentation] Thermogenic UCP1 enhances anorexigenic effect of leptin in mice (2009)
  • Author(s): Yuko Okamatsu-Ogura
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都、京都国際会館
  • Year and Date: 2009-03-30