| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Insertional mutation in giantin(Golgb1) gene is responsible for the developmental abnormalities including osteochondrodysplasia and systemic edema in ocd/ocd rat. ocd/ocd rats exhibited the delayed mesenchymal condensation in chondrogenesis, abnormalities of lyphatic vessels and enhanced vascular permeability. The present findings indicate that the important role of giantin in normal embryonic development, especially chondrogenesis, and formation of lymphatic and blood vessels.
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