Analysis of regulatory mechanism in p66shc-mediated oxidative stress
| Project/Area Number |
21780267
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YAMAMORI Tohru Hokkaido University, 大学院・獣医学研究科, 准教授 (00512675)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 加齢性疾患 / 活性酸素 / 酸化ストレス / p66shc |
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| Research Abstract |
P66shc-deficient mice have a maximum lifespan that was up to 30% greater than that of normal mice and are less susceptible to various aging-associated diseases, such as cardiovascular diseases and diabetes, than normal mice. This study was aimed to elucidate the molecular mechanism behind this phenomenon. We revealed that cellular susceptibility to oxidative stress and ionizing radiation was regulated by p66shc. We also found that hydrogen peroxide was responsible for mediating the oxidative stress to p66shc, and that the interaction between p66shc and Heat shock protein 72 influenced the cellular radiosensitivity.
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] Histone Deacetylase-3 Antagonizes Aspirin-Stimulated Endothelial Nitric Oxide Production by Reversing Aspirin-Induced Lysine Acetylation of Endothelial Nitric Oxide Synthase.2010
Author(s)
Jung SB, Kim CS, Naqvi A, Yamamori T, Mattagajasingh I, Hoffman T, Cole M, Kumar A, Dericco J, Jeon BH, Irani K.
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Journal Title
Circulation Research 107(7)
Pages: 877-887
Related Report
Peer Reviewed
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[Journal Article] A single nucleotide variation in a p53 binding site affects nutrient-sensitive human SIRT1 expression.2010
Author(s)
Naqvi A, Hoffman T, Dericco J, Kumar A, Kim CS, Jung SB, Yamamori T, Kim Y, Mehdi F, Kumar S, Rankinen T, Ravussin E, Irani K.
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Journal Title
Human Molecular Genetics 19(21)
Pages: 4123-4133
Related Report
Peer Reviewed
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