| Project/Area Number |
21780272
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
IGARASHI Manabu Hokkaido University, 人獣共通感染症サーチセンター, 特任助教 (10374240)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 人畜共通感染症 / インフルエンザ / ウイルス / 感染症 / 生体生命情報学 / 計算科学 / 分子シミュレーション / 糖鎖 / 蛋白質 |
|---|
| Research Abstract |
The hemagglutinin (HA) of influenza A viruses undergoes antigenic changes to escape from antibody-mediated immune pressure. In order to control for influenza, it is important to understand the patterns of amino acid substitutions in the past and then to predict possible antigenic changes of the HA molecules in future. In this study, we analyzed the change of HA antigenic structures in the evolutionary process of influenza viruses in the human population, by using structural bioinformatics approach. Based on the results, we predicted possible amino acid substitutions that might be associated with future antigenic change of 2009 H1N1.
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