| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
It is still unclear how rabies viruses enter into the central nervous system from a bite site and then cause rabies. In this study, by serial passaging of the street rabies virus strain 1088 in a neuroblastoma cell line, we established a variant that was attenuated in mice following i. m. but not i. c. infections. We found that addition of an N-glycan to the viral G protein is related to the attenuation. Concerning the additional N-glycosylation is also found in laboratory-adapted strains but not street strains, the N-glycosylation status of the G protein is probably one of the determinants for the rabies virus pathogenicity following peripheral infection.
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