Analysis of fatty acid metabolisms and assessment of therapeutic efficacy of PPARs ligands in feline hepatic lipidosis

Research Project

Project/Area Number	21780287
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Clinical veterinary science
Research Institution	Tottori University
Principal Investigator	NISHII Naohito 鳥取大学, 農学部, 講師 (20508478)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	内科 / 猫 / 肝リピドーシス / PPARs
Research Abstract	Experimental hepatic lipidosis was induced in cats by rapid weight reduction, and therapeutic efficacy of PPARS ligand was assessed. In this study, base sequences of eight molecules that are involved in fatty acid metabolism were determined, and the quantitative method for their expression was established. Administrations of clinofibrate increased hepatic lipid accumulation. This result warns about the danger of clinofibrate use in weight-reducing cats.

Report

(4 results)