| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Oral tributyrin, prodrug of butyrate, increased plasma butyrate level in inferior vena cava and expression of PPARγ and apoptosis in small and large intestine. And tributyrin attenuated intestinal injury associated with lipopolysaccharide injection. The increase in pro-inflammatory cytokine TNF-α/IL-1β mRNA level, pathological changes including hemorrhage, and high mortality were improved by tributyrin. Oral tributyrin increased plasma butyrate level and attenuated intestinal injury in endotoxemic rats.
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