| Project/Area Number |
21780304
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
MITSUTAKE Susumu Hokkaido University, 大学院・先端生命科学研究院, 特任准教授 (10344475)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | セラミド / スフィンゴミエリン / スフィンゴ脂質 / 糖尿病 / ceramide / sphingomyelin / triglyceride / fatty liver |
|---|
| Research Abstract |
Sphingolipids has been demonstrated to be a lipid mediator in a variety of cellular events as a component of lipid microdomain. In this study, we found that the deficiency of SMS2, one of the sphingomyelin synthase, reduced the visceral fat of the mice. We further demonstrated that the physical interaction among SMS2, caveolin, and CD36 was important for the storage of neutral lipids.
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