The role of HMGA1 for the G6Pase gene transcription
Project/Area Number |
21780307
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Applied molecular and cellular biology
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Research Institution | University of Tsukuba |
Principal Investigator |
HIROTA Keiko 筑波大学, 生命環境系, 助教 (00375370)
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Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥6,099,801 (Direct Cost: ¥4,692,155、Indirect Cost: ¥1,407,646)
Fiscal Year 2011: ¥1,549,801 (Direct Cost: ¥1,192,155、Indirect Cost: ¥357,646)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 糖代謝 / 転写制御 / HMGA / インスリン / glucose-6-phosphatase / In vivo LUC / 線虫 / FOXO |
Research Abstract |
Gluconeogenesis, an extremely important metabolic pathway in the regulation of blood glucose levels under fasting conditions, is activated by glucagon and suppressed by insulin. The rate of gluconeogenesis is modulated by the levels of rate-limiting enzymes such as glucose-6-phosphatase (G6Pase). In this study, I analyzed the mechanism of the G6Pase gene expression and revealed that HMGA1 repressed the FOXO1-dependent G6Pase gene activation.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Asymmetric arginine dimethylation determines lifespan in C. elegans by regulating forkhead transcription factor DAF-162011
Author(s)
Takahashi Y, Daitoku H, Hirota, K., Tamiya H, Yokoyama A, Kako K, Nagashima Y, Nakamura A, Watanabe S, Yamagata K, Yasuda K, Ishii N and Fukamizu A
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Journal Title
Cell Metab
Volume: 13
Pages: 505-516
Related Report
Peer Reviewed
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[Journal Article] A nuclear receptor, hepatocyte nuclear factor 4, differently contributes to the human and mouse angiotensinogen promoter activities2010
Author(s)
Oishi, T., Date, S., Shimamoto, Y., Saito, T., Hirota, K., Sugaya, T., Kon, Y., Fukamizu, A., Tanimoto, K
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Journal Title
J. Recept. Signal Transduct
Volume: 30
Pages: 484-492
Related Report
Peer Reviewed
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