Development of Synthetic Methodology for Multi-substituted Heterocycles via Benzyne Intermediate and Its Application for Natural Product Synthesis
| Project/Area Number |
21790006
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
OKANO Kentaro Tohoku University, 大学院・薬学研究科, 助教 (30451529)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 有機化学 / 有機合成化学 / 天然物合成化学 / ベンザイン / 多置換複素環 / イソバツェリン / リンデロールA |
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| Research Abstract |
Synthetic methodology for multi-substituted heterocycles was developed utilizing the high reactivity of benzyne intermediate. Magnesium bisamide was proved to be the best base for the benzyne generation and nucleophilic addition to construct heterocyclic skeletons. The resulting anion species reacted with a variety of electrophiles to give functionalized heteroaromatic compounds. The tricyclic skeleton of isobatzelline and discorhabdins was constructed using the reaction conditions.
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Report
(3 results)
Research Products
(36 results)
