| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The present researches can be summarized as follow. (1) We developed a Pd-catalyzed intramolecular ipso-Friedel-Crafts allylic alkylation of phenols, which provided a new access to spirocyclohexadienones. (2) Novel bidentate-type diaminophosphine oxide preligands were developed and applied to catalytic organic synthesis. In addition, catalytic asymmetric total synthesis of tangutorine was achieved. (3) Novel bifunctional hydrogen bond-donor catalysts based on a 4,5-diaminoxanthene skeleton were developed. These catalysts were applicable to enantioselective conjugate addition of prochiral nucleophiles to nitrostyrenes for constructing an all carbon quaternary stereocenter.
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