Developments and applications of multifunctional catalytic molecules based on the creation of novel asymmetric reaction space
| Project/Area Number |
21790007
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
NEMOTO Tetsuhiro Chiba University, 大学院・薬学研究院, 講師 (80361450)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | ジアミノホスフィンオキシド / 触媒的不斉合成 / 有機触媒 / スピロ化合物 / タングトリン / パラジウム / アリル位置換反応 / 水素結合触媒 / 含窒素化合物合成 / 全合成 |
|---|
| Research Abstract |
The present researches can be summarized as follow. (1) We developed a Pd-catalyzed intramolecular ipso-Friedel-Crafts allylic alkylation of phenols, which provided a new access to spirocyclohexadienones. (2) Novel bidentate-type diaminophosphine oxide preligands were developed and applied to catalytic organic synthesis. In addition, catalytic asymmetric total synthesis of tangutorine was achieved. (3) Novel bifunctional hydrogen bond-donor catalysts based on a 4,5-diaminoxanthene skeleton were developed. These catalysts were applicable to enantioselective conjugate addition of prochiral nucleophiles to nitrostyrenes for constructing an all carbon quaternary stereocenter.
|
Report
(3 results)
Research Products
(43 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Catalytic Asymmetric Total Synthesis of Tangutorine2010
Author(s)
Tetsuhiro Nemoto, Eri Yamamoto, Robert Franzen, Takashi Fukuyama, Riliga Wu, Toshihiko Fuakamachi, Hiroshi Kobayashi, Yasumasa Hamada
Organizer
The 21^<st> French-Japanese Synposium on Medicinal and Fine Chemistry
Place of Presentation
Kyoto, Japan
Year and Date
2010-05-10
Related Report
-
[Presentation] Catalytic Asymmetric Total Synthesis of Tangutorine2010
Author(s)
Tetsuhiro Nemoto, Eri Yamamoto, Robert Franzen, Takashi Fukuyama, Riliga Wu, Toshihiko Fuakamachi, Hiroshi Kobayashi, Yasumasa Hamada
Organizer
The 21^<st> French-Japanese Symposium on Medicinal and Fine Chemistry
Place of Presentation
京都
Year and Date
2010-05-10
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
