Control of ordered structure and functionalization of oligomers linked with nonplanar amides
Project/Area Number |
21790010
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Chemical pharmacy
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Research Institution | The University of Tokyo |
Principal Investigator |
OTANI Yuko The University of Tokyo, 大学院・薬学系研究科, 助教 (60451853)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 二環性アミノ酸 / β-プロリン / ヘリックス / シス-トランス異性化 / オリゴマー / チオアミド / 計算化学 / 二環性β-プロリン誘導体 / 規則構造 / 分子軌道計算 / 溶媒効果 / 非平面アミド / ヘリックス機能化 / アミドのシス-トランス異性化制御 / β-アミノ酸 / 小員環アミド |
Research Abstract |
Methods for synthesis of conformationally constrained β-proline mimics, that is, bridgehead-substituted 7-azabicyclo[2.2.1]heptane-2-endo-carboxylic acids was established. It is revealed that oligomers composed of a bridgehead-substituted β-amino acid take the cis-amide structure, and helical structures based on the cis-amide linkage were generated independently of the number of residues, from the minimalist dimer through the octamer, and irrespective of the solvent including water.
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Report
(3 results)
Research Products
(53 results)
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[Journal Article] Synthesis and Evaluation of Lysophosphatidylserine Analogs as Inducers of Mast Cell Degranulation. Potent Activities of Lysophosphatidyl- threonine and Its 2-Deoxy Derivative2009
Author(s)
Masazumi Iwashita, Kumiko Makide, Taro Nonomura, Yoshimasa Misumi, Yuko Otani, Mayuko Ishida, Ryo Taguchi, Masafumi Tsujimoto, Junken Aoki, Hiroyuki Arai, Tomohiko Ohwada
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Journal Title
Journal of Medicinal Chemistry 52
Pages: 5837-5863
Related Report
Peer Reviewed
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[Presentation] Organic N-Nitrosoamines which release NO or its equivalents upon Visible Light Irradiation : Design, Synthesis and Application to Cells2010
Author(s)
Fumika Karaki, Yoji Kabasawa, Takahiro Yanagimoto, Nobuhiro Umeda, Yasuteru Urano, Tetsuo Nagano, Yuko Otani, Tomohiko Ohwada
Organizer
The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
Place of Presentation
国立京都国際会館(京都府)
Year and Date
2010-06-15
Related Report
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