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Development of Bioactive Heterocycles by Tin-Free C1 Introduction Radical Process

Research Project

Project/Area Number 21790013
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionKyoto University

Principal Investigator

YAMADA Kenichi  京都大学, 大学院・薬学研究科, 准教授 (00335184)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsラジカル / C1単位 / 生理活性物質 / 複素環構築 / 環境調和
Research Abstract

Development of tin-free radical process is an important research field because of the indispensable utility of radical reactions and the toxicity of tin reagents. We have already developed dimethylzinc-and triethylborane-mediated tin-free radical processes. During this research project to increase the scope of our process, we found the acceleration effect of ferric chloride, an interesting reaction switching of alkylidenemalonate, efficient radical accepting ability of N-alkoxycarbonyl-imine, and isocyanate forming reaction of the imine.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (82 results)

All 2012 2011 2010 2009 Other

All Journal Article (32 results) (of which Peer Reviewed: 32 results) Presentation (49 results) Remarks (1 results)

  • [Journal Article] High Performance of N-Alkoxycarbonyl-Imines in Triethylborane-Mediated Tin-Free Radical Addition2012

    • Author(s)
      Kiyoshi Tomioka
    • Journal Title

      J.Org.Chem.

      Volume: 77巻 Issue: 3 Pages: 1547-1553

    • DOI

      10.1021/jo2025042

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemoselective Conversion ofα-Unbranched Aldehyde to Amide,Ester,and Carboxylic Acid by NHC-Catalysis2012

    • Author(s)
      山田健一
    • Journal Title

      Chem. Commun.

      Volume: vol.48 Issue: 1 Pages: 145-147

    • DOI

      10.1039/c1cc15539c

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemoselective Conversion of α-Unbranched Aldehyde to Amide, Ester, and Carboxylic Acid by NHC-Catalysis2012

    • Author(s)
      Ken-ichi Yamada
    • Journal Title

      Chem.Commun.

      Volume: 48 Pages: 145-147

    • NAID

      120004945080

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Steric Tuning of Chiral C2-Symmetric NHC in Gold-Catalyzed Asymmetric Cyclization of 1,6-Enynes2012

    • Author(s)
      Ken-ichi Yamada
    • Journal Title

      Tetrahedron

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Steric Influence of N-Phosphorus-arylimines on the Rhodium-Catalyzed Asymmetric Arylation2011

    • Author(s)
      Hao, X.; Chen, Q.; Yamada, K.; Yamamoto, Y.; Tomioka, K
    • Journal Title

      Tetrahedron

      Volume: 67(35) Issue: 22 Pages: 6469-6473

    • DOI

      10.1016/j.tet.2012.03.107

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Steric Influence of N-Phosphorus-arylimines on the Rhodium-Catalyzed Asymmetric Arylation2011

    • Author(s)
      Kiyoshi Tomioka
    • Journal Title

      Tetrahedron

      Volume: 67巻 Issue: 35 Pages: 6469-6473

    • DOI

      10.1016/j.tet.2011.06.033

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chiral N-Heterocyclic Carbene. Copper(I)-Catalyzed Asymmetric Allylic Arylation of Aliphatic Allylic Bromides : Steric and Electronic Effects on γ-Selectivity2011

    • Author(s)
      Selim, K. B.; Nakanishi, H.; Matsumoto, Y.; Yamamoto, Y.; Yamada, K.; Tomioka, K
    • Journal Title

      J. Org. Chem

      Volume: 76(5) Issue: 5 Pages: 1398-1408

    • DOI

      10.1021/jo102386s

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rhodium-Catalyzed Asymmetric Phenylation of N-Phosphinoylarylimines with Triphenylborane2011

    • Author(s)
      Hao, X.; Chen, Q.; Kuriyama, M.; Yamada, K.; Yamamoto, Y.; Tomioka, K
    • Journal Title

      Catal. Sci. Tech

      Volume: 1(1) Issue: 1 Pages: 62-64

    • DOI

      10.1039/c0cy00083c

    • NAID

      120004205184

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Steric Influence of N-Phosphorus-arylimines on the Rhodium-Catalyzed Asymmetric Arylation2011

    • Author(s)
      Ken-ichi Yamada
    • Journal Title

      Tetrahedron

      Volume: 67 Pages: 6469-6473

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chiral N-Heterocyclic Carbene-Copper(I)-Catalyzed Asymmetric Allylic Arylation of Aliphatic Allylic Bromides : Steric and Electronic Effects on γ-Selectivity.2011

    • Author(s)
      K.Yamada
    • Journal Title

      J.Org.Chem.

      Volume: 76 Pages: 1398-1408

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rhodium-Catalyzed Asymmetric Phenylation of N-Phosphinoylarylimines with Triphenylborane.2011

    • Author(s)
      K.Yamada
    • Journal Title

      Catal.Sci.Tech.

      Volume: 1 Pages: 62-64

    • NAID

      120004205184

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Formal Synthesis of (+)-Allokainic Acid <i>via</i> Thiol-Mediated Acyl Radical Cyclization2010

    • Author(s)
      Yamada, K.; Sato, T.; Hosoi, M.; Yamamoto, Y.; Tomioka, K
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 58 Issue: 11 Pages: 1511-1516

    • DOI

      10.1248/cpb.58.1511

    • NAID

      130000405667

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Radical Addition of an Acetal to Sterically Tuned Enantiomerically Pure N-Sulfinyl Imines2010

    • Author(s)
      Akindele, T.; Yamada, K.; Sejima, T.; Maekawa, M.; Yamamoto, Y.; Nakano, M.; Tomioka, K
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 58 Issue: 2 Pages: 265-269

    • DOI

      10.1248/cpb.58.265

    • NAID

      130000161607

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chiral Carbene Approach to Gold-Catalyzed Asymmetric Cyclization of 1, 6-Enynes2010

    • Author(s)
      Matsumoto, Y.; Selim, K. B.; Nakanishi, H.; Yamada, K.; Yamamoto, Y.; Tomioka, K
    • Journal Title

      Tetrahedron Lett

      Volume: 51(2) Issue: 2 Pages: 404-406

    • DOI

      10.1016/j.tetlet.2009.11.039

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Formal Synthesis of (+)-Allokainic Acid via Thiol-Mediated Acyl Radical Cyclization.2010

    • Author(s)
      K.Yamada
    • Journal Title

      Chem.Pharm.Bull.

      Volume: 58 Pages: 1511-1516

    • NAID

      130000405667

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Radical Addition of an Acetal to Sterically Tuned Enantiomerically Pure N-Sulfinyl Imines2010

    • Author(s)
      K.Yamada
    • Journal Title

      Chem.Pharm.Bull. 58

      Pages: 265-269

    • NAID

      130000161607

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chiral Carbene Approach to Gold-Catalyzed Asymmetric Cyclization of 1,6-Enynes.2010

    • Author(s)
      K.Yamada
    • Journal Title

      Tetrahedron Lett. 51

      Pages: 404-406

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Chiral N-Heterocyclic Carbene/Copper(I)-Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents2010

    • Author(s)
      K.Yamada
    • Journal Title

      Angew.Chem.Int.Ed. 48

      Pages: 8733-8735

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Chiral N-Heterocyclic Carbene/Copper(I)-Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents2009

    • Author(s)
      Selim, K. B, Matsumoto, Y.; Yamada, K.; Tomioka, K
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: 48(46) Issue: 46 Pages: 8733-8735

    • DOI

      10.1002/anie.200904676

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Steric Tuning of the Amidomonophosphane-Rhodium(I) Catalyst in Asymmetric Addition of Arylboroxines to N-Phosphinoyl Aldimines2009

    • Author(s)
      Hao, X.; Kuriyama, M.; Chen, Q.; Yamamoto, Y.; Yamada, K.; Tomioka, K
    • Journal Title

      Org. Lett.

      Volume: 11(19) Issue: 19 Pages: 4470-4473

    • DOI

      10.1021/ol901866y

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Iron Chloride Enhancement of Dimethylzinc-Mediated Radical Conjugate Addition of Ethers and an Amine to Alkylidenemalonates2009

    • Author(s)
      Yamada, K.; Maekawa, M.; Yamamoto, Y.; Nakano, M.; Akindele, T.; Tomioka, K
    • Journal Title

      Tetrahedron Lett

      Volume: 50(44) Issue: 44 Pages: 6040-6043

    • DOI

      10.1016/j.tetlet.2009.08.034

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chiral Amidophosphane-Rhodium(I)-Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids2009

    • Author(s)
      Chen, Q.; Kuriyama, M.; Hao, X.; Soeta, T.; Yamamoto, Y.; Yamada, K.; Tomioka, K
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 57 Issue: 9 Pages: 1024-1027

    • DOI

      10.1248/cpb.57.1024

    • NAID

      130000124206

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Construction of Binaphthyl by the Chiral Diether-Mediated Conjugate Addition of Naphthyllithium to Naphthalenecarboxylic Acid 2,6-Di-t-butyl-4-methoxyphenyl Ester2009

    • Author(s)
      山田健一
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 57 Issue: 7 Pages: 752-754

    • DOI

      10.1248/cpb.57.752

    • NAID

      130000124382

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accessing the Amide Functionality by the Mild and Low-Cost Oxidation of Imine2009

    • Author(s)
      Mohamed, M. A, Yamada, K.; Tomioka, K
    • Journal Title

      Tetrahedron Lett

      Volume: 50(26) Issue: 26 Pages: 3436-3438

    • DOI

      10.1016/j.tetlet.2009.02.174

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of(-)-Lycorine and (-)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade2009

    • Author(s)
      Yamada, K.; Yamashita, M.; Sumiyoshi, T.; Nishimura, K.; Tomioka, K
    • Journal Title

      Org. Lett

      Volume: 11(7) Issue: 7 Pages: 1631-1633

    • DOI

      10.1021/ol9003564

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tandem Conjugate Addition-Aldol Cyclization of 2-Formylbenzylidenemalonate with Ether Radicals by the Mediation of Dimethylzinc2009

    • Author(s)
      Yamada, K.; Maekawa, M.; Akindele, T.; Yamamoto, Y.; Nakano, M.; Tomioka, K
    • Journal Title

      Tetrahedron

      Volume: 65(4) Issue: 4 Pages: 903-908

    • DOI

      10.1016/j.tet.2008.11.009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chiral Amidophosphane-Rhodium(I)-Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids.2009

    • Author(s)
      K.Yamada
    • Journal Title

      Chem.Pharm.Bull. 57

      Pages: 1024-1027

    • NAID

      130000124206

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iron Chloride Enhancement of Dimethylzinc-Mediated Radical Conjugate Addition of Ethers and an Amine to Alkylidenemalonates2009

    • Author(s)
      K.Yamada
    • Journal Title

      Tetrahedron Lett. 50

      Pages: 6040-6043

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tandem Conjugate Addition-Aldol Cyclization of 2-Formylbenzylidenemalonate with Ether Radicals by the Mediation of Dimethylzinc2009

    • Author(s)
      K.Yamada
    • Journal Title

      Tetrahedron 65

      Pages: 903-908

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Construction of Binaphthyl by the Chiral Diether-Mediated Conjugate Addition of Naphthyllithium to Naphthalenecarboxylic Acid BHA Ester2009

    • Author(s)
      K.Yamada
    • Journal Title

      Chem.Pharm.Bull. 57

      Pages: 752-754

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accessing the Amide Functionality by the Mild and Low-Cost Oxidation of Imine.2009

    • Author(s)
      K.Yamada
    • Journal Title

      Tetrahedron Lett. 50

      Pages: 3436-3438

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of (-)-Lycorine and (-)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade.2009

    • Author(s)
      K.Yamada
    • Journal Title

      Org.Lett. 11

      Pages: 1631-1633

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] α.アミノアルキルラジカルのイミンへの付加反応の開発2012

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Final Research Report
  • [Presentation] ピバロイロキシメチルラジカルのアルキリデンマロネートへの共役付加反応2012

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Final Research Report
  • [Presentation] N-Bocイミンに対するピバロイロキシメチルラジカルの付加反応2012

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Final Research Report
  • [Presentation] C2対称ジアルデヒドのベンゾイン縮合による光学活性シクリトール類の合成2012

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Final Research Report
  • [Presentation] Pancratistatinおよびtrans-Dihydronarciclasineの合成研究2012

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 不斉アザマイケル付加-アルキル化-環化連続反応による含窒素複素環の合成2012

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Temperature Dependent High Performance of N-Boc-imine in Triethylborane-Mediated Tin-Free Radical Pivaloyloxymethylation2011

    • Author(s)
      山田健一
    • Organizer
      the 8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Final Research Report
  • [Presentation] NHC-Controlled N, O-Selectivity in the Chemo selective Conversion of Primary Aldehyde to Amide, Ester, and Carboxylic Acid2011

    • Author(s)
      山田健一
    • Organizer
      the 8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Final Research Report
  • [Presentation] A Potentially New Access to Octahydro-Indolizine Alkaloids2011

    • Author(s)
      山田健一
    • Organizer
      the 8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Temperature Dependent High Performance of N-Boc-imine in Triethylborane-Mediated Tin-Free Radical Alkylation2011

    • Author(s)
      山田健一
    • Organizer
      the 10th International Symposium on Organic Reactions
    • Place of Presentation
      慶應義塾大学矢上キャンパス(神奈川県)
    • Year and Date
      2011-11-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Temperature Dependent High Performance of N-Boc-imine in Triethylborane-Mediated Tin-Free Radical Alkylation2011

    • Author(s)
      Ken-ichi Yamada
    • Organizer
      the 10th International Symposium on Organic Reactions
    • Place of Presentation
      慶應義塾大学矢上キャンパス(神奈川県)(招待講演)
    • Year and Date
      2011-11-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 不斉アザマイケル付加-アルキル化-ヘテロ環化連続反応2011

    • Author(s)
      山田健一
    • Organizer
      有機合成化学協会若手セミナー
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2011-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] NHC触媒によるα-非分岐アルデヒドの選択的アミド化2011

    • Author(s)
      山田健一
    • Organizer
      エステル化、及び酸化反応
    • Place of Presentation
      あわぎんホール(徳島県)
    • Year and Date
      2011-11-08
    • Related Report
      2011 Final Research Report
  • [Presentation] ジメチル亜鉛を用いる炭素ラジカルの発生法と極性転換型炭素-炭素結合生成反応の開発2011

    • Author(s)
      山田健一
    • Organizer
      第9回有機合成化学協会関西支部賞受賞講演会
    • Place of Presentation
      有機合成化学協会近畿支部(大阪府)
    • Year and Date
      2011-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 不斉共役付加を利用するPancratistatinの合成研究2011

    • Author(s)
      山田健一
    • Organizer
      第61回日本薬学会近畿支部大会
    • Place of Presentation
      神戸学院大学(兵庫県)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] N-Bocイミンに対するイミドメチルラジカルの付加反応2011

    • Author(s)
      山田健一
    • Organizer
      第61回日本薬学会近畿支部大会
    • Place of Presentation
      神戸学院大学(兵庫県)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] N-Bocイミンに対するピバロイロキシメチルラジカルの付加反応2011

    • Author(s)
      山田健一
    • Organizer
      第61回日本薬学会近畿支部大会
    • Place of Presentation
      神戸学院大学(兵庫県)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] アミノリチオ化.アリール化連続環化反応の開発2011

    • Author(s)
      山田健一
    • Organizer
      第61回日本薬学会近畿支部大会
    • Place of Presentation
      神戸学院大学(兵庫県)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] フェニルチオアルケンをアクセプターとする分子内アミノリチオ化カルボリチオ化連続環化反応2011

    • Author(s)
      山田健一
    • Organizer
      第61回日本薬学会近畿支部大会
    • Place of Presentation
      神戸学院大学(兵庫県)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] NHC触媒によるα-非分岐アルデヒドの選択的アミド化、エステル化、及び酸化反応とN, O選択性2011

    • Author(s)
      山田健一
    • Organizer
      第41回複素環化学討論会
    • Place of Presentation
      熊本市民会館(熊本県)
    • Year and Date
      2011-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Chemo selective Conversion ofα-Unbranched Aldehyde to Amide, Ester, and Carboxylic Acid by NHC-Catalysis2011

    • Author(s)
      山田健一
    • Organizer
      日独有機触媒シンポジウム
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2011-10-14
    • Related Report
      2011 Final Research Report
  • [Presentation] リチウムアミドの不斉共役付加-アルキル化-環化連続反応を鍵とする(.)-kopsinineの形式全合成2011

    • Author(s)
      山田健一
    • Organizer
      第53回天然有機化合物討論会
    • Place of Presentation
      大阪国際交流センター(大阪府)
    • Year and Date
      2011-09-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Temperature Dependent High Performance of N-Boc-imine in Triethylborane-Mediated Tin-Free Radical Alkylation2011

    • Author(s)
      山田健一
    • Organizer
      5th Pacific Symposium on Radical Chemistry
    • Place of Presentation
      ホテルシーモア(和歌山県)
    • Year and Date
      2011-09-25
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] NHC-Catalyzed Chemo selective Amidation of Amines with Aliphatic Aldehydes2011

    • Author(s)
      山田健一
    • Organizer
      5th Chem Comm International Symposium
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2011-05-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Synthesis of Kopsinine by Asymmetric Conjugate Amination Alkylation泡nnulation Process2011

    • Author(s)
      山田健一
    • Organizer
      5th Chem Comm International Symposium
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2011-05-16
    • Related Report
      2011 Final Research Report
  • [Presentation] C2対称キラルNHC. Cu触媒による不斉アリル位アリール化反応2011

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学(静岡県)
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] N-Bocイミンに対するピバロイロキシメチルラジカルの付加反応2011

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学(静岡県)
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] フェニルチオアルケンをアクセプターとする分子内アミノリチオ化カルボリチオ化連続環化反応2011

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学(静岡県)
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] カルベン触媒を用いるアルデヒドと二級アミンのアミド化2011

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学(静岡県)
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] リチウムアミドの不飽和エステルへの不斉共役付加.アルキル化連続反応を鍵とする(.)-kopsinineの合成2011

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学(静岡県)
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Catalytic asymmetric allylic arylation by chiral NHC/Cu catalyst and aryl Grignard reagents2010

    • Author(s)
      山田健一
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Hilton Hawaiian Village(アメリカ)
    • Year and Date
      2010-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Formal Synthesis of Kopsinine by Asymmetric Conjugate Amination. Tandem Alkylation2010

    • Author(s)
      山田健一
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Hilton Hawaiian Village(アメリカ)
    • Year and Date
      2010-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Catalytic Asymmetric Allylic Arylation by Chiral NHC-Cu Catalyst and Aryl Grignard Reagents2010

    • Author(s)
      K.Yamada
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      ハワイコンベンションセンター(アメリカ)
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] カルベン触媒を用いるアルデヒドと二級アミンのアミド化2010

    • Author(s)
      山田健一
    • Organizer
      第60回日本薬学会近畿支部大会
    • Place of Presentation
      摂南大学(大阪府)
    • Year and Date
      2010-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] ジメチル亜鉛を開始剤とするアシロキシメチルラジカルのベンジリデンマロネートへの共役付加反2010

    • Author(s)
      山田健一
    • Organizer
      プロセス化学会2010サマーシンポジウム
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-07-15
    • Related Report
      2011 Final Research Report
  • [Presentation] ジメチル亜鉛を開始剤とするアシロキシメチルラジカルのベンジリデンマロネートへの共役付加反応2010

    • Author(s)
      K.Yamada
    • Organizer
      プロセス化学会サマーシンポジウム
    • Place of Presentation
      船堀タワーホール(東京)
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Formal Synthesis of Kopsinine by Asymmetric Conjugate Amination-Tandem Alkylation2010

    • Author(s)
      山田健一
    • Organizer
      the 5th SKO Joint Symposium
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2010-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Formal Synthesis of Kopsinine by Asymmetric Conjugate Amination. Tandem Alkylation2010

    • Author(s)
      山田健一
    • Organizer
      21st French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      京都ガーデンパレスホテル(京都府)
    • Year and Date
      2010-05-09
    • Related Report
      2011 Final Research Report
  • [Presentation] C2-Symmetric Chiral NHC. Cu-Catalyzed Asymmetric Allylic Arylation2010

    • Author(s)
      山田健一
    • Organizer
      21st French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      京都ガーデンパレスホテル(京都府)
    • Year and Date
      2010-05-09
    • Related Report
      2011 Final Research Report
  • [Presentation] C_2-Symmetric Chiral NHC-Cu-Catalyzed Asymmetric Allylic Arylation2010

    • Author(s)
      K.Yamada
    • Organizer
      21st French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      京都ガーデンパレス(京都)
    • Year and Date
      2010-05-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] C2対称キラルNHC. Cu触媒による不斉アリル位アリール化反応2010

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山大学(岡山県)
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] イミン類のアミドへのPinnick酸化2010

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山大学(岡山県)
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] ジメチル亜鉛を開始剤とするアシロキシメチルラジカルのベンジリデンマロネートへの共役付加反応2010

    • Author(s)
      山田健一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山大学(岡山県)
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] NHC. Copper(I)-catalyzed asymmetric allylic substitution with aryl Grignard reagents2009

    • Author(s)
      山田健一
    • Organizer
      The 22nd International Congress on Heterocyclic Chemistry
    • Place of Presentation
      Delta Hotel(カナダ)
    • Year and Date
      2009-08-01
    • Related Report
      2011 Final Research Report
  • [Presentation] NHC-Copper(I)-catalyzed asymmetric allylic substitution with aryl Grignard reagents2009

    • Author(s)
      K.Yamada
    • Organizer
      The 22nd International Congress of Heterocyclic Chemistry
    • Place of Presentation
      カナダ
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Introduction of Hydroxymethyl Equivalents by Tin-free Radical Reactions2009

    • Author(s)
      K.Yamada
    • Organizer
      Organic Free Radicals Ottawa 2009
    • Place of Presentation
      カナダ
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Introduction of Hydroxymethyl Equivalents by Tin-free Radical Reactions2009

    • Author(s)
      山田健一
    • Organizer
      Organic Free Radicals Ottawa 2009
    • Place of Presentation
      Ottawa University(カナダ)
    • Year and Date
      2009-07-26
    • Related Report
      2011 Final Research Report
  • [Presentation] イミンのアミドへのPinnick酸化反応2009

    • Author(s)
      山田健一
    • Organizer
      プロセス化学会2009サマーシンポジウム
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2009-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] イミンのアミドへのPinnick酸化反応2009

    • Author(s)
      K.Yamada
    • Organizer
      プロセス化学会サマーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-07-16
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kyoto-u.ac.jp/gousei/index.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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