Design of proline analogues based on hybrid methods and their application
| Project/Area Number |
21790018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
DEMIZU Yosuke National Institute of Health Sciences, 有機化学部, 研究官 (90389180)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アミノ酸 / ペプチド / コンフォメーション / フォルダマー / ペプチド触媒 |
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| Research Abstract |
The de novo design of peptides that fold into well-defined secondary structures is crucially important in a wide variety of fields such as organic chemistry, and biological and material sciences. Approaches to controlling the conformations of peptides have been studied, and as templates for stabilizing the secondary structures of peptides, α, α-disubstituted α-amino acids have been widely used. In this study, we demonstrated the synthesis of proline analogues and stabilized short helical peptides, and their application to the enantioselective epoxidation of (E)-chalcone.
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Report
(3 results)
Research Products
(62 results)
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[Presentation] Conformational studies of diastereomeric-Leu-Aib-peptides2010
Author(s)
Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M
Organizer
5th International Peptide Symposium
Place of Presentation
Kyoto
Related Report
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[Presentation] Controlling the helical screw sense of Aib-based peptides with chiral a-amino acids2010
Author(s)
Demizu, Y., Sato, Y., Tanaka, M, Doi, M, Suemune, H, Okuda, H, Kurihara, M
Organizer
PACIFICHEM 2010
Place of Presentation
Honolulu, USA
Related Report
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[Presentation] Structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences2010
Author(s)
Demizu, Y, Doi, M, Sato, Y, Tanaka, M, Okuda, H Kurihara, M
Organizer
31st European Peptide Symposium
Place of Presentation
Copenhagen, Denmark
Related Report
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[Presentation] Development of non-secosteroidal VDR ligands2010
Author(s)
Demizu, Y, Sato, Y, Ochiai, E, Horie, K, Kakua, S, Takimoto-Kamimura, M, Okuda, H, Kurihara, M
Organizer
The 21st French-Japanese Symposium on Medicinal and Fine Chemistry
Place of Presentation
Kyoto
Related Report
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[Presentation] ノンセコステロイド型VDRリガンドの設計と合成2009
Author(s)
出水庸介, 金子文也, 岩井すみれ, 高橋健男, 佐藤由紀子, 落合鋭士, 堀江恭平, 角田真二, 上村みどり, 奥田晴宏, 栗原正明
Organizer
第28回メディシナルケミストリーシンポジウム
Place of Presentation
東京
Related Report
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[Presentation] ノンセコステロイド型VDRリガンドのデノボ設計2009
Author(s)
出水庸介, 金子文也, 岩井すみれ, 高橋健男, 佐藤由紀子, 落合鋭士, 堀江恭平, 角田真二, 上村みどり, 奥田晴宏, 栗原正明
Organizer
第35回反応と合成の進歩シンポジウム
Place of Presentation
金沢
Related Report
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