| Project/Area Number |
21790018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | National Institute of Health Sciences |
|---|
Principal Investigator |
DEMIZU Yosuke National Institute of Health Sciences, 有機化学部, 研究官 (90389180)
|
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
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| Keywords | アミノ酸 / ペプチド / コンフォメーション / フォルダマー / ペプチド触媒 |
|---|
| Research Abstract |
The de novo design of peptides that fold into well-defined secondary structures is crucially important in a wide variety of fields such as organic chemistry, and biological and material sciences. Approaches to controlling the conformations of peptides have been studied, and as templates for stabilizing the secondary structures of peptides, α, α-disubstituted α-amino acids have been widely used. In this study, we demonstrated the synthesis of proline analogues and stabilized short helical peptides, and their application to the enantioselective epoxidation of (E)-chalcone.
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