Synthetic study of GKK1032s, directed toward the development of new anticancer drugs

Research Project

Project/Area Number	21790022
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Chemical pharmacy
Research Institution	Tokyo University of Pharmacy and Life Science (2010-2011) Tohoku Pharmaceutical University (2009)
Principal Investigator	ABE Hideki 東京薬科大学, 生命科学部, 准教授 (00328551)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	GKK1032類 / 不斉合成 / 分子内Diels-Alder反応 / 合成化学 / 多環性アルカロイド / 抗腫瘍性 / 有機化学 / 薬学 / 抗腫瘍活性
Research Abstract	Stereoselective synthesis of the tricyclic decahydrofluorene core(ABC-ring system) of GKK1032s has been accomplished. All attempt for the construction of 13-membered ring of the target compounds(intramolecular Mitsunobu reaction, intramolecular Reformatsky reaction, intramolecular Still coupling reaction, ring closing metathesis, and intramolecular Friedel. Crafts reaction) was failed.

Report

(4 results)