Development of highly selective enyne metathesis based on substituent effect
| Project/Area Number |
21790023
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
IMAHORI Tatsusi Kumamoto University, 大学院・先導機構, 特任助教 (90433515)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | エン-インメタセシス / 置換基効果 / タンデム反応 / 選択性制御 / 反応機構解析 / 水素結合 |
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| Research Abstract |
We found that an allylic hydroxy group can activate the adjacent olefin in Ru-alkylidene catalyzed enyne metathesis. Using the substituent effect of an allylic hydroxy group, acceleration of enyne metathesis, group (ene) -selective eneyne metathesis, and direction controlled enyne metathesis has been accomplished. It was also suggested that the activation effect of an allylic hydroxy group arises from hydrogen-bonding interaction between the substrate and catalyst from mechanistic study.
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Report
(3 results)
Research Products
(6 results)
