| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We found that an allylic hydroxy group can activate the adjacent olefin in Ru-alkylidene catalyzed enyne metathesis. Using the substituent effect of an allylic hydroxy group, acceleration of enyne metathesis, group (ene) -selective eneyne metathesis, and direction controlled enyne metathesis has been accomplished. It was also suggested that the activation effect of an allylic hydroxy group arises from hydrogen-bonding interaction between the substrate and catalyst from mechanistic study.
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