Development of the Asymmetric transformations of N-Aryl Oxindole as a Chiral Building Block
Project/Area Number |
21790026
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Chemical pharmacy
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Research Institution | Nagoya University |
Principal Investigator |
NAKAZAKI Atsuo Nagoya University, 生命農学研究科, 准教授 (00366428)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | オキシインドール / 多環式含窒素天然物 / 軸不斉 / 不斉合成 / 生物活性 |
Research Abstract |
In order to develop new methodology for the synthesis of C3-stereocontrolled oxindoles, chiral racemic N-aryl isatin was synthesized. And diastereoselectivities of its nucleophilic addition were found to be moderate.
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Report
(3 results)
Research Products
(79 results)
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[Journal Article] Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs2010
Author(s)
Toshiaki Aoki, Kensuke Ohnishi, Masaaki Kimoto, Satoshi Fujieda, Kouji Kuramochi, Toshifumi Takeuchi, Atsuo Nakazaki, Nobuo Watanabe, Fumio Sugawara, Takao Arai, Susumu Kobayashi
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Journal Title
Pharmaceuticals Vol.3
Pages: 1063-1069
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[Journal Article] Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs2010
Author(s)
Toshiaki Aoki, Kensuke Ohnishi, Masaaki Kimoto, Satoshi Fujieda, Kouji Kuramochi, Toshifumi Takeuchi, Atsuo Nakazaki, Nobuo Watanabe, Fumio Sugawara, Takao Arai, Susumu Kobayashi
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Journal Title
Pharmaceuticals
Volume: 3
Pages: 1063-1069
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Peer Reviewed
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[Presentation] Total Synthesis of (-)-Diversifolin2010
Author(s)
Kazuma Tsuboi, Tomoaki Nakamura, Takahiro Suzuki, Atsuo Nakazaki, Susumu Kobayashi
Organizer
24th European Colloquium on Heterocyclic Chemistry
Place of Presentation
Vienna University of Technology, Austria
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[Presentation] AngiomotinとAngiostatin及びRoxithromycinとの結合領域及び結合様式の解明2010
Author(s)
高草木香織, 鈴木愛こ, 高草木洋一, 渡辺まどか, 松本勇記, 戸井崎絢, 鈴木孝洋, 中崎敦夫, 菅原二三男, 小林進, 坂口謙吾
Organizer
BMB2010
Place of Presentation
神戸ポートアイランド(兵庫県)
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[Presentation] Synthetic Studies on Biologically Active Natural Products2010
Author(s)
Toshio Nishikawa, Kumi Sugino, Atsuo Nakazaki, Keiko Higuchi, Masaatsu Adachi Nopporn Thasana, Minoru Isobe
Organizer
The 9th NRCT-JSPS Joint Seminar 2010 "Natural Medicine Research for the Next Decade : New Challenges and Future Collaboration"
Place of Presentation
Chulalongkorn University (Bangkok, Thailand)
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[Presentation] Total Synthesis of Norzoanthamine2010
Author(s)
Daisuke Yamashita, Yoshihisa Murata, Naotsuka Hikage, Yohei Minasako, Ken-ichi Takao, Atsuo Nakazaki Takahiro Suzuki, Susumu Kobayashi
Organizer
2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
Place of Presentation
Hawaii Convention Center (Honolulu, USA)
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[Presentation] Total Synthesis of Norzoanthamine2009
Author(s)
Daisuke Yamashita, Yoshihisa Murata, Atsuo Nakazaki, Susumu Kobayashi
Organizer
22nd International Congress on Heterocyclic Chemistry
Place of Presentation
Delta Hotel and Convention Centre (Newfoundland and Labrador, Canada)
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