Development of new spiroborate supramolecular polymers and its application to evaluation and medical treatment

• Project/Area Number: 21790029
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Chemical pharmacy
• Research Institution: Tokushima Bunri University
• Principal Investigator: KAWAHATA Masatoshi Tokushima Bunri University, 香川薬学部, 助教 (00441593)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 自己組織化 / 超分子化学 / ナノ材料 / 分子認識

Research Abstract

To improve the solubility, modified supiroborates were synthesized. Spiroborates including the modified types were reacted with various cations (ammoniums and pyridiniums). And it was clarified the spiroborate has the ability to encapsulate with the ammonium of the amantadine used as a medicine from single crystal X-ray measurement.

Research Products

• [Journal Article] Assembly Modulation by Adjusting Counter Charges of Heterobimetallic Supramolecular Polymers Composed of Tris(spiroborate) Twin Bowls (2010)
  • Author(s): Hiroshi Danjo, Kadzuya Hirata, Masanori Noda, Susumu Uchiyama, Kiichi Fukui, Masatoshi Kawahata, Isao Azumaya, Kentaro Yamaguchi, Toshifumi Miyazawa
  • Journal Title: J.Am.Chem.Soc. 132 Pages: 15556-15558
• [Journal Article] Assembly Modulation by Adjusting Counter Charges of Heterobimetallic Supramolecular Polymers Composed of Tris(spiroborate) Twin Bowls (2010)
  • Author(s): Hiroshi Danjo, * Kadzuya Hirata, Masanori Noda, Susumu Uchiyama, Kiichi Fukui, Masatoshi Kawahata, Isao Azumaya, Kentaro Yamaguchi, Toshifumi Miyazawa
  • Journal Title: J.Am.Chem.Soc. Volume: 132 Pages: 15556-15558
  • Peer Reviewed
• [Presentation] 双方向ゲスト包接型スピロボラートシクロファン複合体の溶液構造 (2011)
  • Author(s): 川幡正俊
  • Organizer: 日本薬学会年会
  • Place of Presentation: ツインメッセ静岡
  • Year and Date: 2011-03-29
• [Presentation] 双方向性包接型スピロボラートシクロファン化合物の結晶構造 (2010)
  • Author(s): 川幡正俊
  • Organizer: 有機微量分析研究懇談会
  • Place of Presentation: 京都大学
  • Year and Date: 2010-05-13
• [Presentation] 双方向ゲスト包接型スピロボレートシクロファン化合物の結晶構造 (2010)
  • Author(s): 川幡正俊
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 桃太郎アリーナ(岡山県)
  • Year and Date: 2010-03-29
• [Presentation] 双方向ゲスト包接型スピロボレートシクロファン化合物の結晶構造
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] 双方向ゲスト包接型スピロボラートシクロファン複合体の溶液構造
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] 双方向性包接型スピロボラートシクロファン化合物の結晶構造
  • Organizer: 有機微量分析研究懇談会
  • Place of Presentation: 米沢
• [Remarks] ホームページ等