Development of artificial pancreas based on an LBL microcapsule

• Project/Area Number: 21790031
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Physical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: SATO Katsuhiko 東北大学, 大学院・薬学研究科, 助教 (80400266)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: クロカプセル / インスリンDD / 機能性薄膜 / 交互累積膜 / フェニルボロン酸 / ミクロカプセル / インスリンDDS

Research Abstract

Sugar-sensitive microcapsules containing insulin (artificial pancreas) were prepared by a layer-by-layer (LBL) deposition of alginic acid and phenylboronic acid-modified poly(allylamine) on the surface of a calcium carbonate (CaCO_3) microparticle in which insulin had been embedded, followed by dissolution of the CaCO_3 core. The sugar-triggered release of insulin was explained on the basis of decomposition of the microcapsules, which in turn was caused by competitive binding of added sugar to the phenylboronic acid moieties in the LbL film.

Research Products

• [Journal Article] インスリンを含有する高分子ミクロカプセルの調製および糖応答性 (2010)
  • Author(s): 佐藤勝彦、児玉大祐、遠藤好弘、吉田健太郎、安斉順一
  • Journal Title: 高分子論文集 Volume: 67 Pages: 544-548
  • NAID: 10026686935
  • Peer Reviewed
• [Journal Article] Sugar-dependent solubility and fluorescence property of copolymers consisting of phenylboronic acid and 2-hydroxyethyl methacrylate moieties (2010)
  • Author(s): Katsuhiko Sato, Tatsuya Nakajima, Yu Yasukawa, Jun-ichi Anzai
  • Journal Title: Polymer Bulletin Volume: 65 Pages: 807-814
  • Peer Reviewed
• [Journal Article] Layer-by-layer polyelectrolyte films containing insulin for pH-triggered release (2010)
  • Author(s): Kentaro Yoshida, Katsuhiko Sato, Jun-ichi Anzai
  • Journal Title: Journal of Materials Chemistry Volume: 20 Pages: 1546-1552
  • Peer Reviewed
• [Presentation] CaCO_3粒子表面での重合反応によるカプセルの調製 (2010)
  • Author(s): 佐藤勝彦, 中島達也, 安斉順一
  • Organizer: 第49回日本薬学会東北支部大会
  • Place of Presentation: 郡山
  • Year and Date: 2010-10-24
• [Presentation] CaCO3粒子表面での重合反応によるカプセルの調製 (2010)
  • Author(s): 佐藤勝彦, 中島達也, 安斉順一
  • Organizer: 第49回日本薬学会東北支部大会
  • Place of Presentation: 郡山
  • Year and Date: 2010-10-24
• [Presentation] グルコースセンサ機能をもつインスリンカプセル (2009)
  • Author(s): 佐藤勝彦, 児玉大祐, 安斉順一
  • Organizer: 第48回化学センサ研究発表会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-10