Evaluation of crystal and molecular state of pharmaceutical salt by MQ-MAS NMR method
| Project/Area Number |
21790032
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | MQ-MAS NMR / 固体NMR / 低含量製剤 / 水和物 / 医薬品金属塩 / 水和物・擬似多形 / ナプロキセンNa / 単結晶X線構造解析 / NMR緩和時間 / 運動性 / Solid State NMR / 金属塩 / 分子状態 / PXRD |
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| Research Abstract |
Multi Quantum Magic Angle Spinning (MQ-MAS) NMR spectroscopy characterized the pseudopolymorphs of sodium naproxen and cromolyn sodium. The detailed structure and molecular state of the pseudopolymorphs were clarified. The discrimination of the pseudopolymorphs in low dose formulation was achieved. This study revealed that MQ-MAS method could be a powerful technique to evaluate pharmaceutical formulations.
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Report
(4 results)
Research Products
(29 results)
