| Project/Area Number |
21790044
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TOMODA Keishiro Tokyo University of Science, 薬学部・薬学科, 助教 (70516400)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | DDS / ナノテクノロジー / 肺がん治療 / 経肺投与 / がん / 製剤学 / ナノメディシン |
|---|
| Research Abstract |
Inhalable nanoparticle formulation for treatment of lung carcinoma was developed. Excipients were added to enhance flowability of nanoparticles. When arginine and glutamine were applied as excipients, the flowability of nanoparticles reached the highest. When the nanoparticles were adiministered to lung carcinoma cells, taken-up nanoparticles increased as the applied dose increased. The uptake amount of nanoparticles with the size of 100 and 200nm became higher than that of 400nm. From these results, it was indicated that inhalable nanocomposite formulation using appropriate excipients and size of nanoparticle into the formulation has a potential for treatment of lung carcinoma.
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