Development of tumor microenvironment responsive nanoparticles and investigation of the antitumor effect
Project/Area Number |
21790049
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Physical pharmacy
|
Research Institution | Kyoto Pharmaceutical University |
Principal Investigator |
HAMA Susumu 京都薬科大学, 薬学部, 助教 (60438041)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | がん微小環境 / ドラッグデリバリー |
Research Abstract |
Novel charge-invertible nanoparticles were developed that can respond to the acidic pH of a tumor. We designed a unique peptide(referred to as a slightly acidic pH sensitive peptide : SAPSP), as a pH responsive device for intelligent nanoparticles consisting of cationic liposomes. The cellular uptake of SAPSP-modified liposomes(SAPSP-lipo) increased at tumoral pH(pH 6. 5) due to conversion of the liposomal surface charge from negative to positive. In addition, siRNA-encapsulated SAPSP-lipo induced a significant knock down effect, but only at pH 6. 5. These results indicate that SAPSP-lipo represents a novel intelligent drug delivery system that can respond to tumoral pH for use in cancer therapy.
|
Report
(4 results)
Research Products
(31 results)