| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Novel charge-invertible nanoparticles were developed that can respond to the acidic pH of a tumor. We designed a unique peptide(referred to as a slightly acidic pH sensitive peptide : SAPSP), as a pH responsive device for intelligent nanoparticles consisting of cationic liposomes. The cellular uptake of SAPSP-modified liposomes(SAPSP-lipo) increased at tumoral pH(pH 6. 5) due to conversion of the liposomal surface charge from negative to positive. In addition, siRNA-encapsulated SAPSP-lipo induced a significant knock down effect, but only at pH 6. 5. These results indicate that SAPSP-lipo represents a novel intelligent drug delivery system that can respond to tumoral pH for use in cancer therapy.
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