| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
The mechanism of generation of reactive oxygen species (ROS) by antioxidants as pro-oxidants was investigated in the presence of a metal ion or under basic conditions. Quercetin, one of polyphenolic antioxidants, was suggested to show the pro-oxidant activity via a complex formation between its carbonyl oxygen and a metal ion. The phenolate anion derived from a vitamin E model in the presence of a strong base showed a strong electron-donating ability to reduce molecular oxygen to produce ROS.
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