Mechanistic Study on the Pro-oxidant Effects by Antioxidants
| Project/Area Number |
21790053
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | National Institute of Radiological Sciences |
|---|
Principal Investigator |
NAKANISHI Ikuo National Institute of Radiological Sciences, 重粒子医科学センター, 主任研究員 (70356137)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 活性酸素種 / 抗酸化物質 / 薬学 / 有機化学 / 反応機構 / ラジカル / プロオキシダント / 金属イオン |
|---|
| Research Abstract |
The mechanism of generation of reactive oxygen species (ROS) by antioxidants as pro-oxidants was investigated in the presence of a metal ion or under basic conditions. Quercetin, one of polyphenolic antioxidants, was suggested to show the pro-oxidant activity via a complex formation between its carbonyl oxygen and a metal ion. The phenolate anion derived from a vitamin E model in the presence of a strong base showed a strong electron-donating ability to reduce molecular oxygen to produce ROS.
|
Report
(3 results)
Research Products
(84 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] 放射線科学2009
Author(s)
中西郁夫
Total Pages
3
Publisher
独立行政法人放射線医学総合研究所
Related Report
-
-
-
