A study to elucidate how AdRP-associated mutations in splicing factors affect the spliceosome formation pathway
| Project/Area Number |
21790056
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
MAITA Hiroshi Hokkaido University, 大学院・薬学研究院, 講師 (60431318)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 分子生物学 / pre-mRNAスプライシング / 遺伝子 / シグナル伝達 / スプライシング / シグナル転達 |
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| Research Abstract |
Although autosomal dominant retinitis pigmentosa (AdRP) is a tissue specific disease, disease associated mutations were found in several constitutive splicing factors consisting the spliceosome as well as genes in photo signal transduction pathway. To elucidate the mechanism how abnormality of general splicing factors triggers AdRP, we tried to detect the effect of the mutations on the cellular splicoeosme levels using a newly developed reporter. The reporter experiment suggested that the cell may regulate the spliceosome level to adjust the surrounding environment.
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Report
(3 results)
Research Products
(10 results)
