| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
Neuronal synapses are critical cell adhesion structures, which are specialized for intercellular signal transduction between neurons. To understand the molecular mechanisms of synaptic formation is one of the important challenges in neuroscience field and provides better understanding of higher brain function such as learning and memory and neurodegenerative diseases. An adapter protein SYD-2 is a key molecule for presynaptic assembly in nematode C.elegans. In this study, we showed that oligomerization is a critical step for the activation of SYD-2, and identified multiple modifier mutants, which may work together with SYD-2 for presynaptic assembly.
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