Development of hypoglycemic drugs using diabetic silkworm model
| Project/Area Number |
21790062
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
MATSUMOTO Yasuhiko The University of Tokyo, 大学院・薬学系研究科, 助教 (60508141)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 糖尿病 / 血糖降下薬 / カイコ / 無脊椎動物モデル / ガラクトース / グルコーストランスポーター2 |
|---|
| Research Abstract |
We have proposed a novel method for development of drugs using invertebrate pathogenic animal model. In this study, we established hyperglycemic model in silkworm and identified galactose as a hypoglycemic drug from herbal medicine, jiou, by monitoring hypoglycemic activity in the hyperglycemic silkworm model. Moreover, we also developed diabetic complication model in silkworm. This is a first report to identify anti-diabetic compound using invertebrate hypoglycemic model.
|
Report
(3 results)
Research Products
(15 results)
