Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Research Abstract |
Insect cytokine PP (paralytic peptide) induce expression of genes for antimicrobial peptide via p38 MAPK pathway in fat body, and activate the phagocytic activity of hemocytes. Regarding the activation of PP, midgut has important role for recognition of cell wall components of bacteria and secret PP-activating factors. In this research, outline of function and activation mechanism of PP in innate immunity response was revealed.
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