| Project/Area Number |
21790064
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HAMAZAKI Jun The University of Tokyo, 大学院・薬学系研究科, 助教 (80533588)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 分子生物学 / プロテアソーム / ショウジョウバエ |
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| Research Abstract |
Proteasome is a essential protease complex that is conserved in eukaryotes. Recently, the proteasomes in higher organisms are known to acquire the diversity and play important roles in biological events. Particularly, the association of the regulation system of the proteasomes and the pathophysiology are noticed. Although, the previously elucidated proteasome regulation system brought from yeast analysis could not applied to higher organisms. To identify novel factor that modulates proteasome function in higher organisms, genetic study was done by using Drosophila melanogaster. As a results, I identified some candidate genes. Now, I am studying the molecular functions of these genes. By using these knowledge, I plan to provide a novel point of view about the aberrant function of the proteasome in human and a molecular basis about the drug discovery targeting the proteasomes.
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