| Project/Area Number |
21790065
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
|
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| Research Institution | Keio University (2010)
Tokyo Medical and Dental University (2009) |
|---|
Principal Investigator |
NAKAMURA Takashi Keio University, 医学部, 助教 (80431948)
|
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| Research Collaborator |
NISHINA Hiroshi 東京医科歯科大学, 難治疾患研究所, 教授 (60212122)
|
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
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| Keywords | DNA損傷応答 / ストレス応答性キナーゼ / ノックアウトマウス / Rassf1c / Rassf1 / RAssflc |
|---|
| Research Abstract |
To define the physiological function of Rassf1c protein, we used gene targeting in mouse embryonic stem cells to generate protein Rassf1c knockout mice. The knockout mice showed significant growth retardation. These results suggest that the ability of mice to repair Rassf1c proteins is essential for normal growth.
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