Elucidation of defensive mechanisms against oxidative stress and search of novel antioxidative substances

• Project/Area Number: 21790070
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kyoto University
• Principal Investigator: IZUMI Yasuhiko Kyoto University, 薬学研究科, 助教 (60456837)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 酸化ストレス / Nrf2-ARE経路 / レチノイン酸

Research Abstract

Nuclear erythroid 2 p45-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway, which induces expression of antioxidant proteins, is a cellular response to oxidative stress. In this study, we clarified the regulatory mechanisms of Nrf2-ARE system and identified a novel activator. First, we examined the effect of bioactive substances on Nrf2-ARE activation by sulforaphan, which is a well-known activator. We found that retinoic acid enhanced sulforaphan-induced ARE activation. Second, we identified a novel activator from extract of Perilla frutescens and clarified the protective effect against 6-hydroxydopamine-induced cell death.

Research Products

• [Journal Article] Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)-antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate. (2011)
  • Author(s): Mizuno, K., Kume, T., Muto, C., Takada-Takatori, Y., Izumi, Y., Sugimoto, H., Akaike, A.
  • Journal Title: J.Pharmacol.Sci. 115 Pages: 320-328
  • NAID: 10029892573
  • Peer Reviewed
• [Journal Article] Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)-antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate. (2011)
  • Author(s): Mizuno, K., Kume, T., Muto, C., Takada-Takatori, Y., Izumi, Y., Sugimoto, H., Akaike, A.
  • Journal Title: J.Pharmacol.Sci. Volume: 115 Pages: 320-328
  • NAID: 10029892573
  • Peer Reviewed
• [Journal Article] Reconstruction and quantitative evaluation of dopaminergic innervation of striatal neurons in dissociated primary cultures. (2010)
  • Author(s): Wakita, S., Izumi, Y., Matsuo, T., Kume, T., Takada-Takatori, Y., Sawada, H.Akaike, A.
  • Journal Title: J.Neurosci.Methods. 192 Pages: 83-89
  • NAID: 120002484968
  • Peer Reviewed
• [Journal Article] Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures. (2010)
  • Author(s): Matsuo, T., Izumi, Y., Kume, T., Takada-Takatori, Y., Sawada, H.Akaike, A.
  • Journal Title: Neurosci. Lett. 481 Pages: 78-81
  • NAID: 120002484966
  • Peer Reviewed
• [Journal Article] Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture. (2010)
  • Author(s): Ohnishi, M., Katsuki, H., Unemura, K., Izumi, Y., Kume, T., Takada-Takatori, Y.Akaike, A.
  • Journal Title: Brain Res. 1347 Pages: 170-178
  • NAID: 120002484967
  • Peer Reviewed
• [Journal Article] Mitogen-activated protein kinases support survival of activated microglia that mediate thrombin-induced striatal injury in organotypic slice culture. (2010)
  • Author(s): Ohnishi, M., Katsuki, H., Izumi, Y., Kume, T., Takada-Takatori, Y.Akaike, A.
  • Journal Title: J.Neurosci.Res. 88 Pages: 2155-2164
  • Peer Reviewed
• [Journal Article] Haloperidol, spiperone, pimozide and aripiprazole reduce intracellular dopamine content in PC12 cells and rat mesencephalic cultures : Implication of inhibition of vesicular transport. (2010)
  • Author(s): Matsuo, T., Izumi, Y., Wakita, S., Kume, T., Takada-Takatori, Y., Sawada, H.Akaike, A.
  • Journal Title: Eur.J.Pharmacol. 640、 Pages: 68-74
  • NAID: 120002426867
  • Peer Reviewed
• [Journal Article] Depolarizing stimuli cause persistent and selective loss of orexin in rat hypothalamic slice culture. (2010)
  • Author(s): Katsuki, H., Kurosu, S., Michinaga, S., Hisatsune, A., Isohama, Y., Izumi, Y., Kume, T.Akaike, A.
  • Journal Title: Peptides 31 Pages: 1131-1138
  • NAID: 120002469577
  • Peer Reviewed
• [Journal Article] Elevation of heme oxygenase-1 by proteasome inhibision affords dopaminergic neuroprotection. (2010)
  • Author(s): Yamamoto, N., Izumi, Y., Matsuo, T., Wakita, S., Kume, T., Takada-Takatori, Y., Sawada, H.Akaike, A.
  • Journal Title: J.Neurosci.Res. 88 Pages: 1934-1942
  • Peer Reviewed
• [Journal Article] Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons. (2010)
  • Author(s): Takada-Takatori, Y., Kume, T., Izumi, Y., Niidome, T., Fujii, T., Sugimoto, H.Akaike, A.
  • Journal Title: J.Pharmacol.Sci. 112 Pages: 265-272
  • NAID: 10027744245
  • Peer Reviewed
• [Journal Article] Dopamine facilitates .-synuclein oligomerization in human neuroblastoma SH-SY5Y cells. (2010)
  • Author(s): Yamakawa, K., Izumi, Y., Takeuchi, H., Yamamoto, N., Kume, T., Akaike, A., Takahashi, R., Shimohama, S.Sawada, H.
  • Journal Title: Biochem. Biophys.Res. Commun. 391 Pages: 129-134
  • Peer Reviewed
• [Journal Article] Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors : role of α4 and α7 receptors in neuroprotection. (2010)
  • Author(s): Akaike, A., Takada-Takatori, Y., Kume, T.Izumi, Y.
  • Journal Title: J.Mol.Neurosci. 40 Pages: 211-216
  • Peer Reviewed
• [Journal Article] Mechanisms of neuroprotective effects of nicotine and acetylcholin esterase inhibitors : role of α4 and α7 receptors in neuroprotection. (2010)
  • Author(s): Akaike, A., Takada-Takatori, Y., Kume, T., Izumi, Y.
  • Journal Title: J.Mol.Neurosci. Volume: 40 Pages: 211-216
  • Peer Reviewed
• [Journal Article] Dopamine facilitates α-synuclein oligomerization in human neuroblastoma SH-SY5Y cells. (2010)
  • Author(s): Yamakawa, K., Izumi, Y., Takeuchi, H., Yamamoto, N., Kume, T., Akaike, A., Takahashi, R., Shimohama, S., Sawada, H.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 391 Pages: 129-134
  • Peer Reviewed
• [Journal Article] Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons. (2010)
  • Author(s): Takada-Takatori, Y., Kume, T., Izumi, Y, Niidome, T., Fujii, T., Sugimoto, H., Akaike, A.
  • Journal Title: J.Pharmacol.Sci. Volume: 112 Pages: 265-272
  • NAID: 10027744245
  • Peer Reviewed
• [Journal Article] Elevation of heme oxygenase-1 by proteasome inhibision affords dopaminergic neuroprotection. (2010)
  • Author(s): Yamamoto, N., Izumi, Y., Matsuo, T., Wakita, S., Kume, T., Takada-Takatori, Y., Sawada, H., Akaike, A.
  • Journal Title: J.Neurosci.Res. Volume: 88 Pages: 1934-1942
  • Peer Reviewed
• [Journal Article] Depolarizing stimuli cause persistent and selective loss of orexin in rat hypothalamic slice culture. (2010)
  • Author(s): Katsuki, H., Kurosu, S., Michinaga, S., Hisatsune, A., Isohama, Y., Izumi, Y., Kume, T., Akaike, A.
  • Journal Title: Peptides Volume: 31 Pages: 1131-1138
  • NAID: 120002469577
  • Peer Reviewed
• [Journal Article] Haloperidol, spiperone, pimozide and aripiprazole reduce intracellular dopamine content in PC12 cells and rat mesencephalic cultures : Implication of inhibition of vesicular transport. (2010)
  • Author(s): Matsuo, T., Izumi, Y., Wakita, S., Kume, T., Takada-Takatori, Y., Sawada, H., Akaike, A.
  • Journal Title: Eur.J.Pharmacol. Volume: 640 Pages: 68-74
  • NAID: 120002426867
  • Peer Reviewed
• [Journal Article] Mitogen-activated protein kinases support survival of activated microglia that mediate thrombin-induced striatal injury in organotypic slice culture. (2010)
  • Author(s): Ohnishi, M., Katsuki, H., Izumi, Y., Kume, T., Takada-Takatori, Y., Akaike, A.
  • Journal Title: J.Neurosci.Res. Volume: 88 Pages: 2155-2164
  • Peer Reviewed
• [Journal Article] Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture. (2010)
  • Author(s): Ohnishi, M., Katsuki, H., Unemura, K., Izumi, Y., Kume, T., Takada-Takatori, Y., Akaike, A.
  • Journal Title: Brain Res. Volume: 1347 Pages: 170-178
  • NAID: 120002484967
  • Peer Reviewed
• [Journal Article] Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures. (2010)
  • Author(s): Matsuo, T., Izumi, Y., Kume, T., Takada-Takatori, Y., Sawada, H., Akaike, A.
  • Journal Title: Neurosci.Lett. Volume: 481 Pages: 78-81
  • NAID: 120002484966
  • Peer Reviewed
• [Journal Article] Reconstruction and quantitative evaluation of dopaminergic innervation of striatal neurons in dissociated primary cultures. (2010)
  • Author(s): Wakita, S., Izumi, Y., Matsuo, T., Kume, T., Takada-Takatori, Y., Sawada, H., Akaike, A.
  • Journal Title: J.Neurosci.Methods. Volume: 192 Pages: 83-89
  • NAID: 120002484968
  • Peer Reviewed
• [Journal Article] Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors : role of alpha4 and alpha7 receptors in neuroprotection. (2010)
  • Author(s): Akaike, A., Takada-Takatori, Y., Kume, T., Izumi, Y.
  • Journal Title: J Mol Neurosci. 40 Pages: 211-216
  • Peer Reviewed
• [Journal Article] Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells. (2010)
  • Author(s): Yamakawa, K., Izumi, Y., Takeuchi, H., Yamamoto, N., Kume, T., Akaike, A., Takahashi, R., Shimohama, S., Sawada, H.
  • Journal Title: Biochem Biophys Res Commun. 391 Pages: 129-134
  • Peer Reviewed
• [Journal Article] Elevation of heme oxygenase-1 by proteasome inhibition affords dopaminergic neuroprotection. (2010)
  • Author(s): Yamamoto, N., Izumi, Y., Matsuo, T., Wakita, S., Kume, T., Takada-Takatori, Y., Sawada, H., Akaike, A.
  • Journal Title: J Neurosci Res.
  • Peer Reviewed
• [Journal Article] Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons. (2010)
  • Author(s): Takada-Takatori, Y., Kume, T., Izumi, Y., Niidome, T., Fujii, T., Sugimoto, H., Akaike, A.
  • Journal Title: J Pharmacol Sci. 112 Pages: 265-272
  • NAID: 10027744245
  • Peer Reviewed
• [Journal Article] Mitogen-activated protein kinases support survival of activated microglia that mediate thrombin-induced striatal injury in organotypic slice culture. (2010)
  • Author(s): Ohnishi, M., Katsuki, H., Izumi, Y., Kume, T., Takada-Takatori, Y., Akaike, A.
  • Journal Title: J Neurosci Res.
  • Peer Reviewed
• [Journal Article] Depolarizing stimuli cause persistent and selective loss of orexin in rat hypothalamic slice culture. (2010)
  • Author(s): Katsuki, H., Kurosu, S., Michinaga, S., Hisatsune, A., Isohama, Y., Izumi, Y., Kume, T., Akaike, A.
  • Journal Title: Peptides.
  • NAID: 120002469577
  • Peer Reviewed
• [Journal Article] Serofendic acid promotes stellation induced by cAMP and cGMP analogs in cultured cortical astrocytes. (2009)
  • Author(s): Kume, T., Ito, R., Taguchi, R., Izumi, Y., Katsuki, H., Niidome, T., Takada-Takatori, Y., Sugimoto, H.
  • Journal Title: J.Pharmacol.Sci. 109 Pages: 110-118
  • NAID: 10025733864
  • Peer Reviewed
• [Journal Article] Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced parkinson's disease models. (2009)
  • Author(s): Takeuchi, H., Yanagida, T., Inden, M., Takata, K., Kitamura, Y., Yamakawa, K., Sawada, H., Izumi, Y., Yamamoto, N., Kihara, T., Uemura, K., Inoue,_H., Taniguchi, T., Akaike, A., Takahashi, R., Shimohama, S.
  • Journal Title: J.Neurosci.Res. 87 Pages: 576-585
  • Peer Reviewed
• [Journal Article] Functional changes induced by long-term stimulation of nicotinic acetylcholine receptors. (2009)
  • Author(s): Takada-Takatori, Y., Kume, T., Izumi, Y., Ohgi, Y., Niidome, T., Fujii, T., Sugimoto, H., Akaike, A.
  • Journal Title: Biol.Pharm.Bull. 32 Pages: 318-324
  • Peer Reviewed
• [Journal Article] Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation. (2009)
  • Author(s): Izumi, Y., Yamamoto, N., Matsuo, T., Wakita, S., Takeuchi, H., Kume, T., Katsuki, H., Sawada, H., Akaike, A.
  • Journal Title: J.Neurochem. 110 Pages: 745-755
  • Peer Reviewed
• [Journal Article] Excitotoxicity-associated p53 expression in adult rat retina is mediated by calpain activity but not by CI- influx. (2009)
  • Author(s): Hama, Y., Katsuki, H., Izumi, Y., Kume, T., Akaike, A.
  • Journal Title: J.Pharmacol.Sci. 110 Pages: 493-496
  • Peer Reviewed
• [Journal Article] Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling. (2009)
  • Author(s): Katsuki, H., Kurimoto, E., Takemori, S., Kurauchi, Y., Hisatsune, A., Isohama, Y., Izumi, Y., Kume, T., Shudo, K., Akaike, A.
  • Journal Title: J.Neurochem. 110 Pages: 707-718
  • Peer Reviewed
• [Presentation] パラコート誘発細胞死における細胞内ヘムの関与 (2011)
  • Author(s): 山本隆盛, 泉安彦, 江角将之, 久米利明, 赤池昭紀
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡、グランシップツインメッセ静岡
  • Year and Date: 2011-03-30
• [Presentation] パラコート誘発細胞死における細胞内ヘムの関与 (2011)
  • Author(s): 山本隆盛, 泉安彦, 江角将之, 久米利明, 赤池昭紀
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡 グランシップ ツインメッセ静岡
  • Year and Date: 2011-03-30
• [Presentation] PC12細胞における細胞外および細胞内ドパミンに対するクルクミンの作用:細胞膜および小胞モノアミントランスポーターの関与 (2011)
  • Author(s): 松尾剛明, 泉安彦, 久米利明, 金子周司, 澤田秀幸, 杉本八郎, 赤池昭紀
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-03-24
• [Presentation] PC12細胞における細胞外および細胞内ドパミンに対するクルクミンの作用:細胞膜および小胞モノアミントランスポーターの関与 (2011)
  • Author(s): 松尾剛明, 泉安彦, 久米利明, 金子周司, 澤田秀幸, 杉本八郎, 赤池昭紀
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜 パシフィコ横浜
  • Year and Date: 2011-03-24
• [Presentation] 培養大脳皮質-線条体切片におけるトロンビン誘発障害とheme oxygenase-1の関与 (2011)
  • Author(s): 大西正俊, 香月博志, 井上敦子, 泉安彦, 久米利明, 赤池昭紀
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-03-23
• [Presentation] ラット心虚血-再灌流障害に対するセロフェンド酸による保護作用 (2011)
  • Author(s): 五百蔵忠明, 赤尾昌治, 久米利明, 井口守丈, 泉安彦, 赤池昭紀
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2011-03-23
• [Presentation] ラット心虚血-再灌流障害に対するセロフェンド酸による保護作用 (2011)
  • Author(s): 五百蔵忠明, 赤尾昌治, 久米利明, 井口守丈, 泉安彦, 赤池昭紀
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜 パシフィコ横浜
  • Year and Date: 2011-03-23
• [Presentation] 培養大脳皮質-線条体切片におけるトロンビン誘発障害とheme oxygenase-1の関与 (2011)
  • Author(s): 大西正俊, 香月博志, 井上敦子, 泉安彦, 久米利明, 赤池昭紀
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜 パシフィコ横浜
  • Year and Date: 2011-03-23
• [Presentation] Neuroprotective effects of nicotine and acetylcholinesterase inhibitors. (2010)
  • Author(s): Akaike, A., Kume, T., Izumi, Y.
  • Organizer: The 20th Japan-Korea Joint Seminar on Pharmacology
  • Place of Presentation: Kagoshima, Kagoshima Public Center
  • Year and Date: 2010-11-25
• [Presentation] トロンビンによる線条体障害を媒介する活性化ミクログリアにおけるMAPキナーゼの役割 (2010)
  • Author(s): 大西正俊, 香月博志, 井上敦子, 泉安彦, 久米利明, 赤池昭紀
  • Organizer: 第118回日本薬理学会近畿部会
  • Place of Presentation: 大阪千里ライフサイエンスセンター
  • Year and Date: 2010-11-19
• [Presentation] 培養線条体細胞におけるsulforaphaneによるNrf2-ARE経路活性化機構の解明 (2010)
  • Author(s): 水野景太, 久米利明, 大西絵里香, 泉安彦, 赤池昭紀
  • Organizer: 第118回日本薬理学会近畿部会
  • Place of Presentation: 大阪千里ライフサイエンスセンター
  • Year and Date: 2010-11-19
• [Presentation] 培養線条体細胞におけるsulforaphaneによるNrf2-ARE経路活性化機構の解明 (2010)
  • Author(s): 水野景太, 久米利明, 大西絵里香, 泉安彦, 赤池昭紀
  • Organizer: 第118回日本薬理学会近畿部会
  • Place of Presentation: 大阪 千里ライフサイエンスセンター
  • Year and Date: 2010-11-19
• [Presentation] トロンビンによる線条体障害を媒介する活性化ミクログリアにおけるMAPキナーゼの役割 (2010)
  • Author(s): 大西正俊, 香月博志, 井上敦子, 泉安彦, 久米利明, 赤池昭紀
  • Organizer: 第118回日本薬理学会近畿部会
  • Place of Presentation: 大阪 千里ライフサイエンスセンター
  • Year and Date: 2010-11-19
• [Presentation] グルココルチコイドは培養大脳皮質アストロサイトにおいてグルココルチコイド受容体の発現低下を介して細胞増殖を抑制する (2010)
  • Author(s): 畝村和宏, 久米利明, 近藤みなみ, 泉安彦, 赤池昭紀
  • Organizer: 第20回日本臨床精神神経薬理学会第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 仙台市仙台国際センター
  • Year and Date: 2010-09-16
• [Presentation] グルココルチコイドは培養大脳皮質アストロサイトにおいてグルココルチコイド受容体の発現低下を介して細胞増殖を抑制する (2010)
  • Author(s): 畝村和宏, 久米利明, 近藤みなみ, 泉安彦, 赤池昭紀
  • Organizer: 第20回日本臨床精神神経薬理学会第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 仙台市 仙台国際センター
  • Year and Date: 2010-09-16
• [Presentation] ロテノンによるタウ蛋白のリン酸化および細胞毒性に関する検討 (2010)
  • Author(s): 本郷春幸, 木原武士, 夏目和明, 泉安彦, 久米利明, 杉本八郎, 赤池昭紀
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム
  • Place of Presentation: 京都市京都大学薬学部
  • Year and Date: 2010-09-11
• [Presentation] アリピプラゾールによるグルタミン酸誘発ドパミンニューロン死に対する保護作用機序の解明 (2010)
  • Author(s): 松尾剛明, 泉安彦, 久米利明, 澤田秀幸, 赤池昭紀
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム
  • Place of Presentation: 京都市京都大学薬学部
  • Year and Date: 2010-09-11
• [Presentation] アリピプラゾールによるグルタミン酸誘発ドパミンニューロン死に対する保護作用機序の解明 (2010)
  • Author(s): 松尾剛明, 泉安彦, 久米利明, 澤田秀幸, 赤池昭紀
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム
  • Place of Presentation: 京都市 京都大学薬学部
  • Year and Date: 2010-09-11
• [Presentation] ロテノンによるタウ蛋白のリン酸化および細胞毒性に関する検討 (2010)
  • Author(s): 本郷春幸, 木原武士, 夏目和明, 泉安彦, 久米利明, 杉本八郎, 赤池昭紀
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム
  • Place of Presentation: 京都市 京都大学薬学部
  • Year and Date: 2010-09-11
• [Presentation] ラット初代培養心筋細胞における酸化ストレスに対するsulforaphaneの保護作用機序の解析 (2010)
  • Author(s): 久米利明, 市川茉莉那, 泉安彦, 赤池昭紀
  • Organizer: 第117回日本薬理学会近畿部会
  • Place of Presentation: 徳島徳島県郷土文化会館
  • Year and Date: 2010-07-08
• [Presentation] ラット初代培養心筋細胞における酸化ストレスに対するsulforaphaneの保護作用機序の解析 (2010)
  • Author(s): 久米利明, 市川茉莉那, 泉安彦, 赤池昭紀
  • Organizer: 第117回日本薬理学会近畿部会
  • Place of Presentation: 徳島 徳島県郷土文化会館
  • Year and Date: 2010-07-08
• [Presentation] Reconstruction of the nigrostriatal projections in dissociated primary cultures : A role of striatal cells in dopaminergic neurite outgrowth. (2010)
  • Author(s): Wakita, S., Izumi, Y., Kume, T., Sawada, H., Akaike, A.
  • Organizer: World Pharma 2010
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2010-06-19
• [Presentation] Neuroprotective effect of serofendic acid on in vitro and in vivo neuronal injury. (2010)
  • Author(s): Kume, T., Izumi, Y., Akaike, A.
  • Organizer: World Pharma 2010
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2010-06-19
• [Presentation] Paraquat activates Nrf2-ARE pathway : implication of decrease in proteasome activity in dopamine-mediated cytotoxicity. (2010)
  • Author(s): Izumi, Y., Matsushima, S., Yamamoto, N., Kume, T., Sawada, H., Akaike, A.
  • Organizer: World Pharma 2010
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2010-06-19
• [Presentation] Neuroprotective effect of serofendic acid on in vitro an in vivo neuronal injury. (2010)
  • Author(s): Kume, T., Izumi, Y., Akaike, A.
  • Organizer: World Pharma 2010
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2010-06-19
• [Presentation] 中脳ドパミンニューロンの突起伸長における線条体ニューロンの役割の解析 (2010)
  • Author(s): 脇田誓子, 泉安彦, 松尾剛明, 山本隆盛, 松村敦子, 久米利明, 澤田秀幸, 赤池昭紀
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター(岡山)
  • Year and Date: 2010-03-30
• [Presentation] 内在性ドパミンとプロテアソーム活性によるドパミンニューロン死の制御機構 (2010)
  • Author(s): 泉安彦, 久米利明, 赤池昭紀
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター(岡山)
  • Year and Date: 2010-03-29
• [Presentation] 網膜の再生・分化を制御する因子 (2010)
  • Author(s): 赤池昭紀, 久米利明, 泉安彦, 小坂田文隆
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-03-18
• [Presentation] ラット脳虚血-再灌流障害に対するセロフェンド酸静脈内投与による保護作用 (2010)
  • Author(s): 五百蔵忠明, 久米利明, 泉安彦, 赤池昭紀
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-03-17
• [Presentation] ラット初代培養心筋細胞における酸化ストレスに対するスルフォラファンの保護作用 (2009)
  • Author(s): 市川茉莉那, 久米利明, 泉安彦, 赤池昭紀
  • Organizer: 第3回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 九州大学 病院地区コラボステーション(福岡)
  • Year and Date: 2009-11-14
• [Presentation] Oxidative stress model induced by microinjection of sodium nitroprusside in mice. (2009)
  • Author(s): Qand Agha Nazari, Mizuno, K., Izumi, Y., Kume, T., Akaike, A.
  • Organizer: 第116回日本薬理学会近畿部会
  • Place of Presentation: ピアザ淡海(大津)
  • Year and Date: 2009-11-13
• [Presentation] パラコート誘発細胞死におけるプロテアソーム活性低下の役割 (2009)
  • Author(s): 松島さやか, 泉安彦, 山本憲幸, 山田俊之, 久米利明, 赤池昭紀
  • Organizer: 第116回日本薬理学会近畿部会
  • Place of Presentation: ピアザ淡海(大津)
  • Year and Date: 2009-11-13
• [Presentation] 培養線条体細胞におけるallyl isothiocyanateの酸化ストレスに対する保護作用機序の解析 (2009)
  • Author(s): 水野景太, 久米利明, 武藤千恵, 泉安彦, 赤池昭紀
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2009
  • Place of Presentation: 慶應義塾大学薬学部(東京都)
  • Year and Date: 2009-08-24
• [Presentation] ラット中大脳動脈閉塞モデルにおけるセロフェンド酸静脈内投与による保護作用 (2009)
  • Author(s): 五百蔵忠明, 久米利明, 泉安彦, 赤池昭紀
  • Organizer: 医療薬学フォーラム2009
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-07-11
• [Presentation] ドパミン受容体アンタゴニストによる細胞内ドパミン量低下作用機序の検討 (2009)
  • Author(s): 松尾剛明, 泉安彦, 脇田誓子, 久米利明, 赤池昭紀
  • Organizer: 第115回日本薬理学会近畿部会
  • Place of Presentation: ホテル金沢(金沢)
  • Year and Date: 2009-06-26
• [Presentation] 中脳初代培養細胞におけるグルタミン酸誘発ドパミンニューロン死に対するS-nitroso-L-cysteineの保護作用 (2009)
  • Author(s): 泉安彦, 久米利明, 赤池昭紀
  • Organizer: 第9回日本NO学会学術集会
  • Place of Presentation: グランシップ(静岡)
  • Year and Date: 2009-05-08