Physiological role of SCN micro-circuit on circadian clock
| Project/Area Number |
21790073
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMAGUCHI Yoshiaki Kyoto University, 薬学研究科, 助教 (30467427)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 体内時計 / 視交叉上核 / グルタミン酸受容体 / 時計遺伝子 / サーカディアンリズム / AMPA受容体 / Per / 概日リズム / アラトスタチン / 神経機能抑制 / リズム同調 / マウス / アデノ随伴ウイルス |
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| Research Abstract |
The glutamatergic neurotransmission in the suprachiasmatic nucleus (SCN) plays a central role in the entrainment of the circadian rhythms to environmental light-dark cycles. Although the glutamatergic effect operating via NMDAR is well elucidated, much less is known about a role of AMPAR in circadian entrainment. Here I show that in vivo microinjection of AMPA in the SCN during the early subjective night phase-delays the behavioral rhythm. These data demonstrate that activation of AMPAR is capable of phase-shifting the circadian clock both in vivo and in vitro, and are consistent with the hypothesis that activation of AMPA receptors is a critical step in the transmission of photic information to the SCN.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus.2011
Author(s)
Doi M, Ishida A, Miyake A, Sato M, Komatsu R, Yamazaki F, Kimura I, Tsuchiya S, Kori H, Seo K, Yamaguchi Y, Matsuo M, Fustin JM, Tanaka R, Santo Y, Yamada H, Takahashi Y, Araki M, Nakao K, Aizawa S, Kobayashi M, Obrietan K, Tsujimoto G, Okamura H.
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Journal Title
Nat Commun 2
Pages: 327-327
NAID
Related Report
Peer Reviewed
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