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The effect of physiological antidepressant treatments on the gene expression pattern in hypothalamic nuclei

Research Project

Project/Area Number 21790074
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKyoto University

Principal Investigator

SEGI Eri  Kyoto University, 薬学研究科, 准教授 (70378628)

Research Collaborator SUGIMOTO Yukihiko  熊本大学, 薬学研究科, 教授
OKUNO Yasushi  京都大学, 薬学研究科, 教授
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords精神分子薬理学 / 抗うつ治療 / 遺伝子発現 / 視床下部 / うつ病 / 電気けいれん療法 / マイクロアレイ解析 / 遺伝子発現変化 / 脳神経疾患 / マイクロアレイ / 遺伝子 / 神経科学 / ストレス
Research Abstract

The exact mechanisms underlying the actions of physiological antidepressant treatment (electroconvulsive therapy) are not yet understood. To identify the gene expression changes by antidepressant treatments in the paraventricular nucleus of hypothalamus (PVN), microarray analysis was performed. I identified several genes as differentially regulated in PVN by electroconvulsive therapy. Although the involvement of the identified gene products in antidepressant effects still remains unknown, some of down-regulated genes, such as protein kinase C and neuropeptide Y, have been reported their relevance to psychological disorders.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis.2010

    • Author(s)
      Esaki Y, Li Y, Sakata D, Yao C, Segi-Nishida E, Matsuoka T, Fukuda K, Narumiya S.
    • Journal Title

      Proc Natl Acad Sci U S A. 107(27)

      Pages: 12233-12238

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling.2010

    • Author(s)
      Tamba S, Yodoi R, Morimoto K, Inazumi T, Sukeno M, Segi-Nishida E, Okuno Y, Tsujimoto G, Narumiya S, Sugimoto Y.
    • Journal Title

      Biochimie.

      Pages: 665-675

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis.2010

    • Author(s)
      Esaki Y, Li Y, Sakata D, Yao C, Segi-Nishida E, Matsuoka T, Fukuda K, Narumiya S
    • Journal Title

      Proc.Natl.Acad.Sci.USA.

      Volume: 107(27) Pages: 12233-12238

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling.2010

    • Author(s)
      Tamba S, Yodoi R, Morimoto K, Inazumi T, Sukeno M, Segi-Nishida E, Okuno Y, Tsujimoto G, Narumiya S, Sugimoto Y
    • Journal Title

      Biochemie

      Volume: 92(6) Pages: 665-675

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner.2009

    • Author(s)
      Yamaoka K, Yano A, Kuroiwa K, Morimoto K, Inazumi T, Hatae N, Tabata H, Segi-Nishida E, Tanaka S, Ichikawa A, Sugimoto Y.
    • Journal Title

      Biochem Biophys Res Commun. 389(4)

      Pages: 678-682

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly.2009

    • Author(s)
      Yodoi R, Tamba S, Morimoto K, Segi-Nishida E, Nishihara M, Ichikawa A, Narumiya S, Sugimoto Y.
    • Journal Title

      Endocrinology.

      Pages: 3345-3352

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of gene expression profiles for different types of mast cells pooled from mouse stomach subregions by an RNA amplification method.2009

    • Author(s)
      Tsuchiya S, Tachida Y, Segi-Nishida E, Okuno Y, Tamba S, Tsujimoto G, Tanaka S, Sugimoto Y.
    • Journal Title

      BMC Genomics. 10

      Pages: 35-35

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of gene expression profiles for different types of mast cells pooled from mouse stomach subregions by an RNA amplification method.2009

    • Author(s)
      Tsuchiya S., et al.
    • Journal Title

      BMC Genomics 10:35

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly.2009

    • Author(s)
      Yodoi R., et al.
    • Journal Title

      Endocrinology 150(7)

      Pages: 3345-3352

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner.2009

    • Author(s)
      Yamaoka K., et al.
    • Journal Title

      Biochem Biophys Res Commun. 389(4)

      Pages: 678-682

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploration of new molecular mechanisms for antidepressant actions of electroconvulsive seizure.

    • Author(s)
      Segi-Nishida E.
    • Journal Title

      Biol.Pharm.Bull. (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exploration of new molecularmechanisms for antidepressant actions of electroconvulsive seizure.

    • Author(s)
      Segi-Nishida E.
    • Journal Title

      Biol.Pharm.Bull.

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Gene profile of electroconvulsive seizures of the paraventricular nucleus of hypothalamus2010

    • Author(s)
      瀬木(西田)恵里(発表者), 他
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] アレルギー性喘息・うつ病を中心とする病態・治療基盤の分子メカニズム研究2010

    • Author(s)
      瀬木(西田)恵里(発表者)
    • Organizer
      日本薬学会・第130年会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] アレルギー性喘息-うつ病を中心とする病態・治療基盤の分子メカニズム研究2010

    • Author(s)
      瀬木(西田)恵里
    • Organizer
      日本薬学会・第130年会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://pharminfo.pharm.kyoto-u.ac.jp/kadai1.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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