The roles of Fgf signaling in development of neurons.

• Project/Area Number: 21790075
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kyoto University
• Principal Investigator: MIYAKE Ayumi Kyoto University, 薬学研究科, 講師 (40346044)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: FGF / ゼブラフィッシュ / 脳・神経形成 / GABA作動性ニューロン / 脳・神経 / 終脳 / 中脳 / 小脳 / 細胞増殖 / 神経細胞死 / オリゴデンドロサイト / ドパミン作動性ニューロン / 間脳

Research Abstract

The specification of GABAergic interneurons and oligodendrocytes by Fgf19 signaling may be mediated through Fgfr1- and Fgfr4-MAPK pathways. It is suggested that Fgf16 and Fgf22 are also involved in the specification of GABAergic interneurons and oligodendrocytes generated in the ventral telencephalon and diencephalon. Furthermore, Fgf22 is involved in cell proliferation and cell survival during embryonic brain development. Fgf22 is also essential for development of the ventral telencephalon and diencephalon.

Research Products

• [Journal Article] The FGF Family in Humans, Mice, and Zebrafish : Development,Physiology, and Pathophysiology (2011)
  • Author(s): S.Sasaki, Y.Nakayama, M.Konishi, A.Miyake, N.Itoh.
  • Journal Title: Genetic Disease (in press)
  • Peer Reviewed
• [Journal Article] The FGF Family in Humans, Mice, and Zebrafish : Development, Physiology, and Pathophysiology (2011)
  • Author(s): S.Sasaki, Y.Nakayama, M.Konishi, A.Miyake, N.Itoh
  • Journal Title: Genetic Disease Volume: (in press)
  • Peer Reviewed
• [Journal Article] A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. (2009)
  • Author(s): A.Miyake, H.Miwa, Y.Kouta, A.Shimada, Y.Yamashita, Y.Nakayama, H.Yamauchi, M.Konishi, N.Itoh.
  • Journal Title: FEBS Lett. 583 Pages: 3643-3648
  • Peer Reviewed
• [Journal Article] Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. (2009)
  • Author(s): A.Miyake, Y.Takahashi, H.Miwa, A.Shimada, M.Konishi, N.Itoh.
  • Journal Title: Biochem. Biophys. Res.Commun. 390 Pages: 1051-1055
  • NAID: 120001750134
  • Peer Reviewed
• [Journal Article] Fgf4 is required for left-right patterning of visceral organs in zebrafish. (2009)
  • Author(s): H.Yamauchi, N.Miyakawa, A.Miyake, N.Itoh.
  • Journal Title: Dev.Biol. 332 Pages: 177-185
  • Peer Reviewed
• [Journal Article] Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. (2009)
  • Author(s): A.Miyake
  • Journal Title: Biochem.Biophys.Res.Commun. 390 Pages: 1051-1055
  • NAID: 120001750134
  • Peer Reviewed
• [Journal Article] A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. (2009)
  • Author(s): H.Miwa, A.Miyake
  • Journal Title: FEBS Lett. 583 Pages: 3643-3648
  • Peer Reviewed
• [Journal Article] Fgf4 is required for left-right patterning of visceral organs in zebrafish. (2009)
  • Author(s): H.Yamauchi
  • Journal Title: Dev.Biol. 332 Pages: 177-185
  • Peer Reviewed
• [Presentation] 脳形成におけるzebrafish neucrinの機能解析 (2010)
  • Author(s): 三宅歩、新野智香、伊藤信行
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] 脳形成におけるzebrafish neucrinの機能解析 (2010)
  • Author(s): 三宅歩、新野智香、伊藤信行
  • Organizer: 第33回 日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-07
• [Presentation] 網膜形成における新規分泌性タンパク質の機能解析 (2009)
  • Author(s): 新野智香、三宅歩、伊藤信行
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-12
• [Presentation] 網膜形成における新規分泌性タンパク質の機能解析 (2009)
  • Author(s): 新野智香、三宅歩、伊藤信行
  • Organizer: 第32回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2009-12-12
• [Remarks] ホームページ等
  • URL: http://www.pharm.kyoto-u.ac.jp/idenshi/