Evaluation of the role of CRTH2, a novel prostaglandin D2 receptor, in higher brain function
| Project/Area Number |
21790077
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
SHINTANI Norihito Osaka University, 大学院・薬学研究科, 准教授 (10335367)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 薬理学 / プロスタグランジン / 遺伝子欠損マウス / CRTH2 / Postaglandin D2 / lipocalin-type prostaglandin D synthase / PACAP / knockout mice / c-Fos expression / sickness behaviors / motivation / prostaglandin D2 / photic entrainment / psychomotor behaviors / PC12 cells |
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| Research Abstract |
In this study, I aimed to determine the central function of CRTH2 by using agonists, antagonists, and knockout mice of CRTH2. I found that CRTH2 is involved in light-induced phase advance of circadian rhythm, lipopolysaccharide (LPS)-induced decrease of novel-object exploration behavior, and 15-deoxy-PGJ2 enhancement of nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. These results demonstrate for the first time the role of CRTH2 in higher brain function.
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Report
(3 results)
Research Products
(44 results)
