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Evaluation of the role of CRTH2, a novel prostaglandin D2 receptor, in higher brain function

Research Project

Project/Area Number 21790077
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionOsaka University

Principal Investigator

SHINTANI Norihito  Osaka University, 大学院・薬学研究科, 准教授 (10335367)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords薬理学 / プロスタグランジン / 遺伝子欠損マウス / CRTH2 / Postaglandin D2 / lipocalin-type prostaglandin D synthase / PACAP / knockout mice / c-Fos expression / sickness behaviors / motivation / prostaglandin D2 / photic entrainment / psychomotor behaviors / PC12 cells
Research Abstract

In this study, I aimed to determine the central function of CRTH2 by using agonists, antagonists, and knockout mice of CRTH2. I found that CRTH2 is involved in light-induced phase advance of circadian rhythm, lipopolysaccharide (LPS)-induced decrease of novel-object exploration behavior, and 15-deoxy-PGJ2 enhancement of nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. These results demonstrate for the first time the role of CRTH2 in higher brain function.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (44 results)

All 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (35 results) Remarks (3 results)

  • [Journal Article] 15d-prostaglandin J_2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells.2010

    • Author(s)
      Hatanaka M, Shibata N, Shintani N, Haba R, Hayata A, Hashimoto H, Baba A.
    • Journal Title

      J Pharmacol Sci. 113(1)

      Pages: 89-93

    • NAID

      10027745228

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] PACAP-deficient mice exhibit light parameter-dependent abnormalities on nonvisual photoreception and early activity onset.2010

    • Author(s)
      Kawaguchi C, Isojima Y, Shintani N, Hatanaka M, Guo X, Okumura N, Nagai K, Hashimoto H, Baba A.
    • Journal Title

      PLoS One 5(2)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of autonomic nerve activities by central pituitary adenylate cyclase-activating polypeptide.2010

    • Author(s)
      Tanida M, Shintani N, Morita Y, Tsukiyama N, Hatanaka M, Hashimoto H, Sawai H, Baba A, Nagai K.
    • Journal Title

      Regul Pept. 161(1-3)

      Pages: 73-80

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of prostanoid CRTH2 receptor in the promoting effects of 15d-PGJ_2 on the NGF-induced neurite outgrowth in PC12 cells.2010

    • Author(s)
      Hatanaka M., et.al.
    • Journal Title

      J. Pharmacol. Sci. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of autonomic nerve activities by central pituitary adenylate cyclase-activating polypeptide.2010

    • Author(s)
      Tanida M, et al.
    • Journal Title

      Regul.Pept. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PACAP-deficient mice exhibit light parameter-dependent abnormalities on nonvisual photoreception and early activity onset.2010

    • Author(s)
      Kawaguchi C, et al.
    • Journal Title

      PLoSOne 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Lipopolysaccharide腹腔内投与で誘発される精神機能変化の解析2010

    • Author(s)
      新谷紀人, 他
    • Organizer
      第60回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 概日リズムの前進性光同調選択的なリポカリン型プロスタグランジンD_2合成酵素(L-PGDS)の関与2010

    • Author(s)
      黒見藍, 畑中道賢, 新谷紀人, 他
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2010
    • Place of Presentation
      京都
    • Year and Date
      2010-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 特定のsickness behavior発現における脳内CRTH2の選択的関与2010

    • Author(s)
      羽場亮太, 新谷紀人, 他
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2010
    • Place of Presentation
      京都
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 強制水泳試験時の行動調節におけるCRTH2の役割2010

    • Author(s)
      尾中勇祐, 羽場亮太, 王海波, 新谷紀人, 他
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2010
    • Place of Presentation
      京都
    • Year and Date
      2010-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] II型プロスタグランジンD2受容体(CRTH2/DP_2)の中枢機能2010

    • Author(s)
      新谷紀人
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2010
    • Place of Presentation
      京都
    • Year and Date
      2010-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 概日リズムの前進性光同調選択的なリポカリン型プロスタグランジンD2合成酵素(L-PGDS)の関与2010

    • Author(s)
      黒見藍、畑中道賢、新谷紀人, 他
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2010
    • Place of Presentation
      京都
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 強制水泳試験時の行動謂節におけるCRTH2の役割2010

    • Author(s)
      尾中勇祐、羽場亮太、王海波、新谷紀人, 他
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2010
    • Place of Presentation
      京都
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] II型プロスタグランジンD2受容体(CRTH2/DP2)の中枢機能2010

    • Author(s)
      新谷紀人
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2010
    • Place of Presentation
      京都
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] CRTH2遺伝子欠損マウスの行動薬理学的特性2010

    • Author(s)
      尾中勇祐, 羽場亮太, 新谷紀人, 他
    • Organizer
      第117回日本薬理学会近畿部会
    • Place of Presentation
      徳島
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 精神行動・情動機能制御における中枢CRTH2の役割2010

    • Author(s)
      新谷紀人, 他
    • Organizer
      CRTH2研究会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-02-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 精神行動・情動機能制御における中枢CRTH2の役割2010

    • Author(s)
      新谷紀人, 他
    • Organizer
      CRTH2研究会 (招待)
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2010-02-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sickness behavior発現における中枢プロスタグランジンDP2受容体の選択的役割2010

    • Author(s)
      新谷紀人, 他
    • Organizer
      第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      宮城
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of a prostanoid receptor CRTH2 in the LPS-induced decrease in object exploration behavior2010

    • Author(s)
      Haba R, Shintani N, et al.
    • Organizer
      Neuro2010(第33回日本神経科学会・第53回日本神経化学会・第20回日本神経回路学会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Specific involvement of prostaglandin D2 signaling in the light-induced phase advance of circadian rhythm2010

    • Author(s)
      Shintani N, et al.
    • Organizer
      Official Satellite Symposium of the 14th International Congress of Endcrinology (GPCR2010)
    • Place of Presentation
      Kyoto Garden Palace, Kyoto(招待シンポジウム)
    • Related Report
      2010 Final Research Report
  • [Presentation] LPS誘発sickness behaviorに対する新規プロスタノイド受容体CRTH2の関与2010

    • Author(s)
      羽場亮太, 新谷紀人, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] Mice lacking L-PGDS showed specific impairment in the light-induced phase advance of locomotor rhythm2010

    • Author(s)
      Hatanaka M, Shintani N, et al.
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of novel prostanoid receptor CRTH2 in LPS-induced sickness behaviors2010

    • Author(s)
      Haba R, Shintani N, et al.
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Sickness behavior発現における中枢プロスタグランジンDP2受容体の選択的役割2010

    • Author(s)
      新谷紀人, 他
    • Organizer
      第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会 合同年会
    • Place of Presentation
      宮城県仙台市
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of a prostanoid receptor CRTH2 in the LPS-induced decrease in object exploration hehavior2010

    • Author(s)
      R.Haba, N.Shintani, et al.
    • Organizer
      Neuro2010(第33回日本神経科学会・第53回日本神経化学会・第20回日本神経回路学会 合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Specific involvement of prostaglandin D2 signaling in the light-induced phase advance of circadian rhythm2010

    • Author(s)
      Norihito Shintani, et al.
    • Organizer
      Official Satellite Symposium of the 14th International Congress of Endcrinology (GPCR2010)(招待シンポジウム)
    • Place of Presentation
      Kyoto Garden Palace, Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] LPS誘発sickness behaviorに対する新規プロスタノイド受容体CRTH2の関与2010

    • Author(s)
      羽場亮太, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター他(岡山県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mice lacking L-PGDS showed specific impairment in the light-induced phaseadvance of locomotor rhythm2010

    • Author(s)
      Michiyoshi Hatanaka, et al.
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Involvement of novel prostanoid receptor CRTH2 in LPS-induced sickness behaviors2010

    • Author(s)
      Ryota Haba, et al.
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Lypopolysaccharide (LPS)誘発sickness behaviorに対するPGD_2・TXA_2受容体拮抗薬ラマトロバンの作用2009

    • Author(s)
      王海波, 羽場亮太, 新谷紀人, 他
    • Organizer
      第116回日本薬理学会近畿部会
    • Place of Presentation
      滋賀
    • Year and Date
      2009-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Lypopolysaccharide (LPS)誘発sickness behaviorに対するPGD2・TXA2受容体拮抗薬ラマトロバンの作用2009

    • Author(s)
      王海波, 他
    • Organizer
      第116回日本薬理学会近畿部会
    • Place of Presentation
      ピアザ淡海(滋賀県)
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] PGD_2受容体CRTH2アゴニストのオープンフィールド行動に対する作用2009

    • Author(s)
      羽場亮太, 畑中道賢, 新谷紀人, 他
    • Organizer
      第115回日本薬理学会近畿部会
    • Place of Presentation
      金沢
    • Year and Date
      2009-06-26
    • Related Report
      2010 Final Research Report
  • [Presentation] PGD2受容体CRTH2アゴニストのオープンフィールド行動に対する作用2009

    • Author(s)
      羽場亮太, 他
    • Organizer
      第115回日本薬理学会近畿部会
    • Place of Presentation
      ホテル金沢(石川県)
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of a novel signaling cascade specifically involved in the light-induced phase advance of circadian rhythm by using PACAP knockout mice2009

    • Author(s)
      Hatanaka M, Shintani N, et al.
    • Organizer
      The 9th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      鹿児島
    • Related Report
      2010 Final Research Report
  • [Presentation] 15-Deoxy-Δ-prostaglandin J_2 enhances NGF-induced neurite outgrowth in PC12 cells via a CRTH2 receptor-p38 MAP kinase pathway2009

    • Author(s)
      Shibata N, Hatanaka M, Shintani N, et al.
    • Organizer
      The 9th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      鹿児島
    • Related Report
      2010 Final Research Report
  • [Presentation] L-PGDS-PGD2- CRTH2 signaling is a novel signaling cascade specifically involved in light-induced phase advance of circadian rhythm2009

    • Author(s)
      Shintani N, et al.
    • Organizer
      第36回国際生理学会世界大会(IUPS2009)
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 精神運動機能調節におけるCRTH2受容体の役割に関する行動薬理学的検討2009

    • Author(s)
      羽場亮太, 畑中道賢, 新谷紀人, 他
    • Organizer
      第6回GPCR研究会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of a novel signaling cascade specifically involved in the light-induced phase advance of circadian rhythm by using PACAP knockout mice2009

    • Author(s)
      Michiyoshi Hatanaka, et al.
    • Organizer
      The 9th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      鹿児島サンロイヤルホテル(鹿児島県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 15-Deoxy-△-prostaglandin J2 enhances NGF-induced neurite outgrowth in PC12 cells via a CRTH2 receptor-p38 MAP kinase pathway2009

    • Author(s)
      Norihiro Shibata, et al.
    • Organizer
      The 9th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      鹿児島サンロイヤルホテル(鹿児島県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] L-PGDS-PGD2-CRTH2 signaling is a novel signaling cascade specifically involved in light-induced phase advance of circadian rhythm2009

    • Author(s)
      Norihito Shintani, et al.
    • Organizer
      第36回国際生理学会世界大会 (IUPS2009)
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 精神運動機能調節におけるCRTH2受容体の役割に関する行動薬理学的検討2009

    • Author(s)
      羽場亮太, 他
    • Organizer
      第6回GPCR研究会
    • Place of Presentation
      日本科学未来館(東京都)
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://molpharm.umin.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://molpharm.umin.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b010/

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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