Molecular mechanisms in two cell death-types, necrosis and apoptosis, induced by 5-fluoro-2'-deoxyuridine
| Project/Area Number |
21790078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
SATO Akira Okayama University, 大学院・医歯薬学総合研究科, 助教 (40530663)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 細胞死 / ネクローシス / アポトーシス / プロテオーム解析 / トランスクリプトーム解析 / Heat shock protein 90 / 転写因子 / 細胞骨格 / Cytokeratin-19 / Lamin-B1 / 5-Fluoro-2'-deoxyuridine |
|---|
| Research Abstract |
We have investigated the cell-death mechanisms of necrosis and apoptosis induced by this anti-tumor drug. We found that the nuclear inner membrane protein lamin-B1, the cytoplasmic intermediate filament-protein cytokeratin-19, and the transcription factor may have key roles in regulating cell-death morphology.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line.2010
Author(s)
Sato A., Naito T., Hiramoto A., Goda K., Omi T., Kitade Y., Sasaki T., Matsuda A., Fukushima M., Wataya Y., Kim H.-S.
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Journal Title
FEBS Journal 277
Pages: 4464-4473
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Peer Reviewed
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[Presentation] 抗腫瘍性ヌクレオシドアナログ3-Ethynylcytidine (ECyd)によるアポトーシス誘導機構の解明2010
Author(s)
大見拓也, 内藤智春, 佐藤聡, 平本晃子, 松田彰, 佐々木琢磨, 福島正和, 北出幸夫, 金惠淑, 綿矢有佑
Organizer
第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
Place of Presentation
神戸,兵庫
Year and Date
2010-12-10
Related Report
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[Presentation] Hye-Sook Kim. Molecular mechanisms of cell death induced by 3'-ethynylcytidine.2010
Author(s)
Yusuke Wataya, Akira Sato, Tomoharu Naito, Takuya Omi, Akiko Hiramoto, Yukio Kitade, Takuma Sasaki, Akira Matsuda, Masakazu Fukushima, Hye-Sook Kim.
Organizer
The 37^<th> International Symposium on Nucleic Acids Chemistry 2010
Place of Presentation
Yokohama, Japan.
Year and Date
2010-11-10
Related Report
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[Presentation] 抗腫瘍性ヌクレオシドアナログ3'-Ethynylcytidine (ECyd, TAS-106)によるアポトーシス誘導機構の解明2010
Author(s)
大見拓也, 内藤智春, 佐藤聡, 平本晃子, 松田彰, 佐々木琢磨, 福島正和, 北出幸夫, 金惠淑, 綿矢有佑
Organizer
第130年会日本薬学会
Place of Presentation
岡山,岡山
Year and Date
2010-03-30
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[Presentation] Molecular Mechanisms of Apoptosis induced by 3'-Ethynylcytidine.2009
Author(s)
Yusuke Wataya, Tomoharu Naito, Akira Sato, Akiko Hiramoto, Yukio Kitade, Takuma Sasaki, Akira Matsuda, Masakazu Fukushima, Hye-Sook Kim
Organizer
Sixth International Symposium on Nucleic Acids Chemistry
Place of Presentation
Takayama, Gifu, Japan.
Year and Date
2009-09-29
Related Report
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