Formation of signaling complex in P2Y12 receptor-mediated microglial chemotaxis.
| Project/Area Number |
21790080
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|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
SAITOH Hidetoshi Kyushu University, 薬学研究院, 助教 (90444794)
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|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 神経生物学 / ATP受容体 / ミクログリア / 神経科学 / イメージング / 脂質ラフト |
|---|
| Research Abstract |
This study established a method which achieved effective transgene expression in primary microglia from neonatal rat forebrain using lentiviral vectors possessing iba1 promoter and transgenes. In addition, this study revealed that two chemokine, CCL2 and CCL3, are upregulated by activation of P2Y12 receptor in primary microglia.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.2011
Author(s)
Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji R-R, Salter MW, Inoue K
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Journal Title
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[Book] Int Rev Neurobiol 852009
Author(s)
Inoue K, Koizumi S, Kataoka A, Tozaki-Saitoh H, Tsuda M
Publisher
Chapter 12 P2Y(6)-Evoked Microglial Phagocytosis.
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