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Roles of the minor sialic acid molecular species in hippocampal dependent memory

Research Project

Project/Area Number 21790085
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

AKIRA Minami  静岡県立大学, 薬学部・生化学教室, 助教 (80438192)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords糖鎖 / 記憶 / 海馬 / 神経 / シアル酸分子種 / シアリダーゼ / インビボ解析 / 酵素活性イメージング / シアル酸 / 電気生理 / インビボ / ラット
Research Abstract

N-Acetylneuraminic acid(Neu5Ac), the major molecular species of sialic acid, is contained in mammalian brain abundantly and plays crucial roles in many neural functions including memory. However, roles of other minor molecular species of sialic acid were poorly understood. In this project, we found the roles of the minor sialic acid molecular species in hippocampal dependent memory.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2012 2011 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (31 results)

  • [Journal Article] Imaging of sialidase activity in rat brain sections by a highly sensitive fluorescent histochemical method2011

    • Author(s)
      Minami, A., Shimizu, H., Meguro, Y., Shibata, N., Kanazawa, H., Ikeda, K., and Suzuki, T
    • Journal Title

      NeuroImage

      Volume: 58 Issue: 1 Pages: 34-40

    • DOI

      10.1016/j.neuroimage.2011.06.017

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plaque Formation Assay for Human Parainfluenza Virus Type 12011

    • Author(s)
      Keijo Fukushima
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 34 Issue: 7 Pages: 996-1000

    • DOI

      10.1248/bpb.34.996

    • NAID

      130000738086

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiviral effect of strictinin on influenza virus replication.2010

    • Author(s)
      Saha RK
    • Journal Title

      Antiviral Research

      Volume: 88(1) Pages: 10-18

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラット海馬の神経興奮に伴うシアリダーゼ活性の変化2012

    • Author(s)
      南彰
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット海馬に発現するシアリダーゼの記憶形成における役割2012

    • Author(s)
      齋藤正和
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] N-グリコリルノイラミン酸のラット脳内分布および体内動態の解析2012

    • Author(s)
      田口理紗
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of Fluorescent Substrates having Sialic Acid Derivatives for Analysis of Sialidase Activities2011

    • Author(s)
      Kiyosi Ikeda
    • Organizer
      8^<th> AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Influenzaウマインフルエンザウイルスのシアリダーゼのシアル酸分子種認識性2011

    • Author(s)
      鵜沼沙織
    • Organizer
      日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会2011
    • Place of Presentation
      愛知
    • Year and Date
      2011-11-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Imaging of sialidase activity in rat brain sections by a highly sensitive fluorescent histochemical method2011

    • Author(s)
      Akira Minami
    • Organizer
      The 4^<th> International Conference on Health and Longevity Sciences
    • Place of Presentation
      Shizuoka
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 記憶におけるN-グリコリルノイラミン酸の影響2011

    • Author(s)
      南彰
    • Organizer
      USフォーラム2011
    • Place of Presentation
      静岡
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ラット脳内におけるN-グリコリルノイラミン酸の分布解明2011

    • Author(s)
      稲田真里
    • Organizer
      第75回日本生化学会中部支部例会・シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 海馬におけるN-グリコリルノイラミン酸高発現ラットの構築および学習能に及ぼす影響2011

    • Author(s)
      田口理紗
    • Organizer
      第75回日本生化学会中部支部例会・シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 新規人工合成基質を利用したラット脳内におけるシアリダーゼ活性の分布解明2011

    • Author(s)
      福元北斗
    • Organizer
      第75回日本生化学会中部支部例会・シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ラット海馬依存性記憶におけるシアリダーゼの役割2011

    • Author(s)
      齋藤正和
    • Organizer
      第75回日本生化学会中部支部例会・シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] シアリダーゼの海馬神経興奮に伴う活性変化と神経伝達物質放出に対する作用のインビボ解析2011

    • Author(s)
      崔紗希
    • Organizer
      第75回日本生化学会中部支部例会・シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 海馬神経興奮と連動した細胞表面シアリダーゼ活性の変化2011

    • Author(s)
      南彰
    • Organizer
      第75回日本生化学会中部支部例会・シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] スルファチドのラット海馬における分布と海馬初代培養細胞における発現変化2011

    • Author(s)
      柴田直紀
    • Organizer
      日本薬学会 第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット海馬におけるシアリダーゼ活性の分布と神経興奮に伴う変化2010

    • Author(s)
      目黒裕芙子
    • Organizer
      第33回日本日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ラット海馬神経興奮に伴ったシアル酸分子種脱離のインビボ解析2010

    • Author(s)
      石橋さやか
    • Organizer
      平成22年度日本薬学会東海支部例会
    • Place of Presentation
      静岡
    • Year and Date
      2010-11-28
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] シアリダーゼ活性のラット海馬における分布と神経興奮に伴う変化2010

    • Author(s)
      目黒裕芙子
    • Organizer
      平成22年度日本薬学会東海支部例会
    • Place of Presentation
      静岡
    • Year and Date
      2010-11-28
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] シアル酸分子種のラット脳内分布と記憶における役割の解明2010

    • Author(s)
      南彰
    • Organizer
      乳酸菌研究会
    • Place of Presentation
      松本
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] シアリダーゼの機能解明を目指したシアル酸誘導体を含む蛍光基質の合成研究2010

    • Author(s)
      池田潔
    • Organizer
      第36回反応と合成の進歩シンポジウム
    • Place of Presentation
      愛知
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] シアリダーゼの機能解明を目指したシアル酸誘導体を含む蛍光基質の合成と酵素活性の測定2010

    • Author(s)
      池田潔
    • Organizer
      第14回生体触媒化学シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enhancement of extracellular sialidase activity in rat hippocampus by neural excitation2010

    • Author(s)
      Akira Minami
    • Organizer
      13^<th> International Conference on Biologyand Chemistry of Sialic Acids
    • Place of Presentation
      Germany
    • Year and Date
      2010-08-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Enhancement of extracellular sialidase activity in rat hippocampus by neural excitation2010

    • Author(s)
      Akira Minami
    • Organizer
      13^<th> International Conference on Biology and Chemistry of Sialic Acids
    • Place of Presentation
      ドイツ
    • Year and Date
      2010-08-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 海馬依存性記憶の形成過程にけるシアル酸分子種の機能解明2010

    • Author(s)
      南彰
    • Organizer
      USフォーラム2010
    • Place of Presentation
      静岡
    • Year and Date
      2010-08-03
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] シアリダーゼ活性のラット脳内分布と神経興奮に伴う変化2010

    • Author(s)
      南彰
    • Organizer
      USフォーラム2010
    • Place of Presentation
      静岡
    • Year and Date
      2010-08-03
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Enhancement of extracellular sialidase activity in rat hippocampus by epileptic seizure2010

    • Author(s)
      Akira Minami
    • Organizer
      The 28^<th> Naito Conference on Glycan Expression and Regulation[I]: Fnctions and disease mechanisms
    • Place of Presentation
      Hayama
    • Year and Date
      2010-07-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Enhancement of extracellular sialidase activity in rat hippocampus by epileptic seizure2010

    • Author(s)
      Akira Minami
    • Organizer
      The 28^<th> Naito Conference on Glycan Expression and Regulation [I] : Functions and disease mechanisms
    • Place of Presentation
      葉山
    • Year and Date
      2010-07-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット海馬におけるシアル酸分子種含有糖鎖の発現2010

    • Author(s)
      南彰
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット海馬におけるシアル酸分子種含有糖鎖の発現2010

    • Author(s)
      南彰
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山桃太郎アリーナ(岡山県)
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット脳内におけるシアリダーゼ活性の分布と神経興奮に伴う変化2010

    • Author(s)
      清水裕貴
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット脳内におけるシアル酸分子種の分布2009

    • Author(s)
      中島さや香
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2009
    • Place of Presentation
      四日市
    • Year and Date
      2009-11-23
    • Related Report
      2011 Final Research Report
  • [Presentation] シアリダーゼ酵素活性のラット脳内分布と神経活動に伴う変化2009

    • Author(s)
      清水裕貴
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2009
    • Place of Presentation
      四日市
    • Year and Date
      2009-11-23
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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