Molecular assembly in functional Ca^<2+> microdomain in vascular smooth muscle cells
| Project/Area Number |
21790087
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
YAMAMURA Hisao Nagoya City University, 大学院・薬学研究科, 講師 (80398362)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | イオンチャネル / カルシウムシグナル / 平滑筋 / 全反射蛍光顕微鏡 / 高血圧 / カリウムチャネル / カルシウムチャネル / リアノジン受容体 / カベオリン / マイクロドメイン / 一分子可視化 / 血管平滑筋 |
|---|
| Research Abstract |
Calcium sparks occur as spontaneous calcium release in subplasmalemmal regions under physiological and pathological conditions in smooth muscle cells. Spatiotemporal imaging of molecular assembly and calcium dynamics in functional calcium microdomain using a total internal reflection fluorescence microscope enables us to elucidate its physiological impact in the regulation of membrane excitability and myogenic tone in vascular smooth muscle cells.
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Report
(3 results)
Research Products
(37 results)
