Investigation of a novel mechanism of cholinergic activation for cognitive impairment treatment
| Project/Area Number |
21790091
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
OKUDA Takashi Keio University, 薬学部, 講師 (00322040)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 認知症 / コリン作動性神経 / アセチルコリン / コリントランスポーター / トラフィッキング / 高親和性コリントランスポーター / 細胞内移行 / アセチルコリン合成 |
|---|
| Research Abstract |
Cholinergic neurons are involved in cognitive function in the central nervous system. At the cholinergic presynaptic terminals, acetylcholine synthesis relies on the high-affinity choline transporter (CHT1) for efficient choline supply from extracellular fluid. The choline uptake is the rate-limiting step in acetylcholine synthesis. We find that extracellular substrate regulates the cell surface CHT1 by enhancing its internalization rate. We also find that tetrahydropyrimidines are competitive inhibitors of CHT1.
|
Report
(3 results)
Research Products
(12 results)
-
[Journal Article] Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase.2009
Author(s)
Fujii, T., Masai, M., Misawa, H., Okuda, T., Takada-Takatori, Y., Moriwaki, Y., Haga, T., Kawashima, K.
-
Journal Title
J.Neurosci.Res. 87
Pages: 3024-3032
Related Report
Peer Reviewed
-
[Journal Article] Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand.2009
Author(s)
Moriwaki, Y., Watanabe, Y., Shinagawa, T., Kai, M., Miyazawa, M., Okuda, T., Kawashima, K., Yabashi, A., Waguri, S., Misawa, H.
-
Journal Title
Neurosci.Res. 64
Pages: 403-412
Related Report
Peer Reviewed
-
[Journal Article] Expression of SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells.2009
Author(s)
Horiguchi, K., Horiguchi, S., Yamashita, N., Irie, K., Masuda, J., Takano-Ohmuro, H., Himi, T., Miyazawa, M., Moriwaki, Y., Okuda, T., Misawa, H., Ozak,i H., Kawashima, K.
-
Journal Title
J.Neurosci.Res. 87
Pages: 2740-2747
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
