The role of uPAR on the LPS-induced bone resorption.

• Project/Area Number: 21790097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Doshisha Women's College of Liberal Arts
• Principal Investigator: KANNO Yosuke Doshisha Women's College of Liberal Arts, 薬学部, 助教 (40416178)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: LPS / uPAR / 炎症性骨破壊 / 破骨細胞

Research Abstract

We found that the absent of uPAR attenuated LPS-induced osteoclast differentiation and bone destruction. In addition, we found that uPAR regulated LPS-induced osteoclast differentiation through NF-kB pathway. Moreover, The inhibitor of integrin pathway attenuated uPAR-increased osteoclasts differentiation. These data suggest that uPAR plays a pivotal role on the LPS-induced osteoclasts differentiation.

Research Products

• [Journal Article] Plasminogen/Plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function. (2011)
  • Author(s): Yosuke Kanno, Akira Ishisaki, Eri Kawashita, Naoyuki Chosa, Keiichi Nakajima, Tatsuji Nishihara, Kuniaki Toyoshima, Kiyotaka Okada, Shigeru Ueshima, Kenji Matsushita, Osamu Matsuo, Hiroyuki Matsuno
  • Journal Title: J Biol Chem. 286 Pages: 8952-8960
  • Peer Reviewed
• [Journal Article] Plasminogen/Plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function. (2011)
  • Author(s): Kanno Y, et al.
  • Journal Title: J Biol Chem. Volume: 286 Pages: 8952-60
  • Peer Reviewed
• [Journal Article] uPAR is associated with the development of adipose tissue. (2010)
  • Author(s): Yosuke Kanno, Hiroyuki Matsuno, Eri Kawashita, Kiyotaka Okada, Hidetaka Suga, Shigeru Ueshima, Osamu Matsuo
  • Journal Title: Thrombosis and Heamostasis 104 Pages: 1124-1132
  • Peer Reviewed
• [Journal Article] Alpha 2-antiplasmin is associated with the progression of fibrosis. (2010)
  • Author(s): Yosuke Kanno, Eri Kawashita, Misato Minamida, Aki Kaneiwa, Kiyotaka Okada, Shigeru Ueshima, Osamu Matsuo, Hiroyuki Matsuno
  • Journal Title: Am J Pathol. 176 Pages: 238-245
  • Peer Reviewed
• [Journal Article] uPAR is associated with the development of adipose tissue. (2010)
  • Author(s): Kanno Y, et al.
  • Journal Title: Thrombosis and Heamostasis Volume: 104 Pages: 1124-32
  • Peer Reviewed
• [Journal Article] Alpha 2-antiplasmin is associated with the progression of fibrosis (2010)
  • Author(s): Kanno Y et al.
  • Journal Title: American Journal of Pathology 176 Pages: 238-245
  • Peer Reviewed
• [Journal Article] Alpha 2-antiplasmin is associated with the progression of fibrosis. (2010)
  • Author(s): Kanno Y, et al.
  • Journal Title: American Journal of Pathology. Volume: 176 Pages: 238-245
  • Peer Reviewed
• [Presentation] Plasminogen/Plasminは、骨芽細胞と破骨細胞を制御する事によって骨代謝を制御している (2010)
  • Author(s): Yosuke Kanno, Akira Ishisaki, Eri Kawashita, Keiichi Nakajima, Kiyotaka Okada, Shigeru Ueshima, Osamu atsuo, Hiroyuki Matsuno
  • Organizer: 第33回日本分子生物学会年会 第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] Plasmin and a2-antiplasmin modulate bone metabolism by regulating the osteoblast and osteoclast function. (2010)
  • Author(s): Yosuke Kanno, Eri Kawashita, Kiyotaka Okada, Shigeru Ueshima, Osamu Matsuo, Hiroyuki Matsuno
  • Organizer: The 20th International Congress of the ISFP
  • Place of Presentation: Amsterdam
• [Presentation] Plasmin and α2-antiplasmin modulate bone metabolism by regulating the osteoblast and osteoclast function. (2010)
  • Author(s): Kanno Y, et al.
  • Organizer: The 20th International Congress of the ISFP
  • Place of Presentation: Amsterdam
• [Presentation] Plasminogen/Plasminは、骨芽細胞と破骨細胞を制御する事によって骨代謝を制御している (2010)
  • Author(s): Kanno Y, et al.
  • Organizer: 第33回日本分子生物学会年会 第83回 日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] 線維化病態におけるalpha2-antiplasminの役割 (2009)
  • Author(s): 菅野陽介、河下映里、岡田清孝、上嶋繁、松尾理、松野浩之
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 線維化病態におけるalpha2-antiplasmin の役割 (2009)
  • Author(s): 菅野陽介, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Remarks] ホームページ等