| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Pathological angiogenesis in patients with ischemic retinal diseases such as diabetic retinopathy results in visual loss and blindness, because the newly formed vessels are quite leaky and can cause vitreous hemorrhage. We previously reported that a dramatic upregulation of apelin expression cause exuberant endothelial cell proliferation and pathological angiogenesis in retinas of oxygen-induced retinopathy model. Here, we demonstrate that in vivo delivery of apelin siRNA to retina resulted in suppression of pathological angiogenesis in oxygen-induced retinopathy model.
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