| Project/Area Number |
21790102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Fukuoka University |
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Principal Investigator |
TAKATA Fuyuko Fukuoka University, 薬学部, 助教 (70412575)
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| Research Collaborator |
KATAOKA Yasufumi 福岡大学, 薬学部, 教授 (70136513)
DOHGU Shinya 福岡大学, 薬学部, 准教授 (60399186)
MATSUMOTO Junichi 福岡大学, 薬学部, 助教 (10550064)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経生物学 / 脳ペリサイト / 肥満 / 血液脳関門 / MMP-9 |
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| Research Abstract |
Brain pericytes are periendothelial accessory structures of the blood-brain barrier (BBB) and integral members of the neurovascular unit. Although neuron-glial cell interactions are essential for cerebral functions, an interaction between pericytes and neuron has still unknown. Our results suggested that pericytes would increase insulin sensitivity and decrease production of AgRP in hypothalamic neuron through soluble factors under physiological condition. On the other hand, we demonstrated that BBB permeability was significantly increased at obese mice with impaired glucose tolerance induced by high-fat diet. TNF-α, which is increased in obesity, induced pericyte-derived MMP-9, leading to BBB dysfunction. Therefore, pericytes and pericytal MMP-9 may be involved in BBB dysfunction in and development of obesity.
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