Pharmacological studies on responsiveness of 5-hydroxytryptamine to overcome perioperative spasm of coronary artery bypass graft in diabetes mellitus
| Project/Area Number |
21790104
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Kyushu University of Health and Welfare |
|---|
Principal Investigator |
TOTORIBE Naoko Kyushu University of Health and Welfare, 薬学部, 講師 (70322576)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
|
|---|
| Keywords | 薬理学 / 糖尿病 / バイパス血管 |
|---|
| Research Abstract |
Diabetes mellitus (DM) could enhance 5-HT-induced vasocontraction via the activation of 5-HT2A and 5-HT1B receptors of the human internal thoracic artery (ITA) and saphenous vein (SV). The enhanced vasocontractions to 5-HT in DM were mediated by the activation of Rho/Rho kinase pathways. Insulin inhibited 5-HT-induced vasocontraction in SV. These results inducate the useful pharmacological findings to prevent 5-HT-induced vasospasm when the human ITA and SV from patients with DM were used as an arterial graft.
|
Report
(3 results)
Research Products
(20 results)
