| Project/Area Number |
21790105
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MAKINO Asami The Institute of Physical and Chemical Research, 小林脂質生物学研究室, 特別研究員 (20373368)
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|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脂肪滴 / 小胞体 / コレステロール / VLDL / ACAT / ADRP / Rab18 / ApoB / 肝細胞 / トリグリセリド / 脂質ドメイン |
|---|
| Research Abstract |
Cholesterol loading in ER induced the enlargement of lipid droplets and the degradation of major LD protein, adipose differentiation-related protein (ADRP) in cultured human hepatocytes. However, lipid particles were not disappeared. Instead, the lipids were surrounded by VLDL protein, ApoB. This step was controlled by rab18. These results indicate that cholesterol modulates both biogenesis/maintenance of LDs and ApoB secretion.
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