| Project/Area Number |
21790110
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
FUJII Shinya Tokyo Medical and Dental University, 大学院・疾患生命科学研究部, 助教 (60389179)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 薬学 / 有機化学 / 生理活性 / 医薬化学 / 核内受容体 / ホウ素クラスター / ノンセコステロイド / ビタミンD |
|---|
| Research Abstract |
Activated vitamin D (1α,25(OH)_2D_3) regulates various physiological processes by binding to its specific nuclear receptor vitamin D receptor (VDR). In this research, potent non-secosteroidal VDR ligands bearing a boron cluster as hydrophobic core structure were developed. Structural development of boron cluster derivatives revealed structure-activity relationship of novel VDR ligands bearing spherical hydrophobic core.
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