Intracellular delivery of therapeutic molecules using functional cell-penetrating peptides that target specific cells
Project/Area Number |
21790112
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Drug development chemistry
|
Research Institution | Kyoto University |
Principal Investigator |
NAKASE Ikuhiko Kyoto University, 化学研究所, 助教 (40432322)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 膜透過ペプチド / 薬物送達 / 細胞標的 / 細胞内送達 / アルギニンペプチ / 受容体標的 / 細胞マーカー / 細胞膜通過 / 細胞選択性 / アルギニンペプチド / マクロピノサイトーシス / プロテオグリカン |
Research Abstract |
Cell-penetrating peptides (CPPs) have been used as carriers to efficiently deliver various types of molecules that are difficult to internalize into cells by themselves. In this research, to examine cell-specific delivery using functional CPPs bearing specific-molecule target sequences was conducted. Using leucine zipper peptides, we ascertained cell-specific internalization of CPP through target-sequence expressed cell membranes with less cytotoxicity.
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Report
(3 results)
Research Products
(78 results)
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[Journal Article] Enhanced target-specific accumulation of radiolabeled antibodies by conjugating arginine-rich peptides as anchoring molecules.2010
Author(s)
R.Miyamoto, H.Akizawa, T.Nishikawa, T.Uehara, Y.Azuma, I.Nakase, S.Futaki, H.Hanaoka, Y.Iida, K.Endo, Y.Arano.
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Journal Title
Bioconjug. Chem. 21
Pages: 2031-2037
Related Report
Peer Reviewed
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[Journal Article] Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4.2010
Author(s)
K.Shimane, E.N.Kodama, I.Nakase, S.Futaki, Y.Sakurai, Y.Sakagami, X.Li, T.Hattori, S.G.Sarafianos, M.Matsuoka.
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Journal Title
Int.J.Biochem.Cell Biol. 42
Pages: 1482-1488
Related Report
Peer Reviewed
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[Journal Article] Rev-derived Peptides Inhibit HIV-1 Replication by Antagonism of Rev and a Co-receptor, CXCR42010
Author(s)
Kazuki Shimane, Eiichi N.Kodama, Ikuhiko Nakase, Shiroh Futaki, Yasuteru Sakurai, Yasuko Sakagami, Xiaoguang Li, Toshio Hattori, Stefan G.Sarafianos, Masao Matsuoka
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Journal Title
The International Journal of Biochemistry & Cell Biology
Volume: 42
Pages: 1482-1488
Related Report
Peer Reviewed
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[Journal Article] Enhanced Target-specific Accumulation of Radiolabeled Antibodies by Conjugating Arginine-rich Peptides as Anchoring Molecules2010
Author(s)
Rei Miyamoto, Hiromichi Akizawa, Takeshi Nishikawa, Tomoya Uehara, Yusuke Azuma, Ikuhiko Nakase, Shiroh Futaki, Hirofumi Hanaoka, Yasuhiko Iida, Keigo Endo, Yasushi Arano
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Journal Title
Bioconjugate Chemistry
Volume: 21
Pages: 2031-2037
Related Report
Peer Reviewed
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